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UConn NUSC
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Epidemiology
Study of diet, disease, and health patterns
Depletion Repletion Study
Nutrient is eliminated in the diet until deficiency symptoms are appear, nutrients are added back in until symptoms are gone (usually done on rodents)
Ethical studies must…
Be approved by the Institutional Board Review (IRB), subjects sign consent forms
Dietary reference intake (DRI)
Recommendations for amounts of energy (macronutrients, micronutrients) and other food components we should consume to remain healthy
Changes depending on gender and age
EER
Estimated Energy Requirement
Acceptable Macronutrient Distribution Range: AMDR
Provides acceptable intake ranges for energy-yielding nutrients
Expressed as a %
Recommended Macronutrient Ranges
45-65% calories from carbs
20-35% from fat
10-35% from protein
RDA
Recommended dietary allowance: amount that meets the needs of 97-98% of people
Ex.) % of daily value
EAR
Estimated Average requirements
The amount of nutrients that is estimated to meet the needs of 50% of people in the same gender and age group
AI
Adequate Intake (more specific/accurate), Estimate for when there is not enough evidence to establish an EAR and RDA
UL
Tolerable upper limit intake level (more crude)
Safety, mostly for certain vitamins
5 things used to calculate someones EER:
Gender
Age
Physical activity level
Weight
Height
What is an eating/dietary pattern?
Combos of food and beverages that make up an individuals intake overtime
Current dietary guidelines are…
Added sugar—> less than 10% of calories each day
Saturated fat—>less than 10% if calories a day
(starting at 2 years)
Sodium—> Less than 2300 mg a day (less if under 14)
Physical Activity guidelines…
150-300 mins a week/half hour a day minimum
Who regulates food labels?
FDA and USDA
DV
Daily value: Amount of nutrients the average person should consume/not consume in a day, on the basis of the 2,000 calories diet
% daily value is…
The % represents the percentage out of 100% that food item makes up of a certain nutrient
Ex.) Calcium 36% —> Thats 36% of your 100% total calcium value for the day
First nutrients labeled on packages and the ones the nation is most deficient in are?
Vitamin D
Calcium
Iron
Potassium
USP
Symbol that indicates that a supplement has been verified for quality
Nutrient content claims, and are they established by the FDA?
Low fat, reduced, antioxidant
Established by the FDA
Health claims, and are they regulated by the FDA?
‘Reduce risk of heart disease,’
FDA regulated
Structure/Function claims, is it regulated by the FDA?
Describes role of nutrient in the body, Ex) Calcium for healthy bones
NOT FDA regulated
Ingredient lists must go by…
WEIGHT
Differences and similarities between my plate vs. Healthy Eating plate are…
Healthy Eating Plate: Limit red meat, eat chicken fish, beans, nuts, avoid processed meat—>More details, recommends oils and water
Myplate: Recommends dairy, less detailed, does not include oil
BOTH say plate should be half grains and proteins, ¼ fruit and the rest veggie
4 stages of Nutritional Defficency:
Inadequate Intake—>Decreased stores+tissue levels—> Altered biochemical and physiological functions—>physical signs of symptoms and deficiency
Organization of Life order
Cell (molecules) —>Tissue (Similar cells) —> Organ (special function) —> organ system (everything working together)—>body
Systems of the body
Digestive system, nervous system, cardiovascular system, endocrine system (releases hormones into the bloodstream), respiratory system, integumentary system (skin, hair)
Brain
When you are hungry—>signals the trigger of enzymes to message the digestive system to prepare for food
CCK
Triggered hormone by the brain to the gallbladder—>tells it to secrete bile in the SI
Gastrin
Hormone that cues the stomach to prepare digestive fluids
Bile
Digestive fluid produced by your liver and stored in your gallbladder to aid in breaking down dietary fats and vitamins
Mouth
Begins the breakdown of food utilizing salivary glands, which contain enzymes like amylase to begin breaking food down into its smallest components
Lysozyme
Blocks bacterial growth that contributes to tooth decay
Bolus
Initial lump of food formed by your mouth
What enzyme breaks down carbs into glucose?
Amylase
Pharynx
Flap before the esophagus that separates your airway and the path your food travels down
Epiglottis
Blocks air passages to the lungs as food moves down the digestive track
Esophagus
tube your food travels down to get to your stomach, connects pharynx and stomach
Peristalas
Muscular contractiuons that moves food down the esophagus
Sphincter
Regulates the passage of food to the stomach
Stomach
Breaks down and temporarily stores your food before digestion, produces hydrochloric acid
Mucus
Secretion used to help lubricate to keep stomach and SI healthy
Hydrochloric acid + bolus =
Chyme
Small intestine
Where absorption of nutrients occurs, everything is absorbed together in its smallest form

Segmentation
Chyme is mixed with digestive fluids and everything becomes one, enhancing the nutrients absorption process
Small Intestine Cells
Produces intestinal juices that aid with absorption
Pancreas
Produces pancreatic juice which contains both
bicarbonate ions (keeps body fluid and blood at the correct PH) and digestive enzymes
Liver
Produces bile which is a fluid that digests fat
Gallbladder
Stores and Secretes bile into the SI
Carbs break down into…
Glucose
The enzyme used to break down carbs is:
Amylase
Carbohydrate digestion process
Amylase breaks down starch into double sugars and short glucose chains—>Enzymes break chains and double sugars apart—> simple sugars travel through the body using blood vessels
Proteins break down into…
Amino Acids
Protein digestion process
Trypsin and chymotrypsin—> break down polypeptides and short amino acid chains—> chains become individual amino acids—> amino acids travel via blood vessels
Fat digestion process
Bile breaks down large fat molecules—> pancreatic lipase breaks them down into free fatty acids and monoglycerides—>short chain is absorbed back into the blood, long fatty acid chains enter the lymphatic system
Enzymes used to break down proteins are…
Pepsin, Trypsin, Chymotrypsin (Trypsin and Chymotrypsin are in the SI)
Pepsinogen cycle
Pepsinogen and hydrochloric acid —>pepsin, which breaks down proteins into amino acids
Fat breaks down into…
Fatty Acids
Enzyme used to break down fat is…
Lipase
Large Intestine
Made up of colon and rectum, absorbs water vitamins and minerals, doesn’t directly participate in digestion, compacts unabsorbed substances into feces, holds most microorganisms
Mix of Microorganisms includes:
Bacteria, fungi, protozoa, viruses
Probiotics
Helps contain natural LIVE gut beneficial bacteria
Ex) Kimchi, yogurt
Prebiotics
Helps stimulate probiotic growth, they pass undigested into the colon
Ex) Bannana, onion, artichokes, garlic