MICRO STI

Genital Ulcer Diseases

HSV, Syphilis, Chancroid

HSV Clinical Disease

multiple painful ulcers, erythematous base: PCR

Syphilis Clinical Disease

single, indurated painless ulcer: darkfield

Chancroid Clinical Disease

multiple painful ulcers: PCR

Urethritis and Cervicitis

chlamydia, gonorrhea

Chlamydia Clinical Disease

purulent discharge, obligate intracellular bacteria

Gonorrhea Clinical Disease

purulent discharge, gram negative diplococci: Chocolate Agar

Vaginitis (Fluconazole/Metronidazole)

Candida albicans, Gardnerella vaginalis, Trichomonas vaginalis

Vaginal Candidiasis Clinical Disease

white clumpy discharge; KOH

Bacterial Vaginosis Clinical Disease

malodorous, thin gray discharge; “clue cells”

Trichomoniasis Clinical Disease

malodorous, green-yellow discharge; “strawberry cervix”

cancer-causing HPV

16, 18

wart-causing HPV

6, 10, 11

primary syphilis

chancre at site of infection; regional lymphadenopathy

secondary syphilis

disseminated rash, generalized lymphadenopathy

tertiary syphilis

gummas, cardiovascular disease, neurological complications

congenital syphilis

snuffles, Hutchinson’s incisors, keratitis, iritis

HIV gag

capsid proteins

HIV pol

RT, protease, integrase

HIV env

gp120, gp41

gp120 function

initial surface binding receptor

gp41 function

stalk protein for HIV binding receptor