NBEO-Immunology (Non big 8)

Most antigens are composed of _________.

protein

______________ are specific complex areas of the antigen that are recognized as foreign and result in the production of antibodies.

Antigen determinant sites

Which of the following is NOT a primary location where antigens are found?

A) Blood

B) Smooth muscle

C) Connective tissue

D) Lymph

C) Connective tissue

Antibodies are considered ___________ globulin plasma proteins.

A) Alpha

B) Beta

C) Delta

D) Gamma

D) Gamma

Does an antigen bind to the Fab or Fc region of an antibody?

Fab region

Does the Fab or Fc portion of an antibody contain both heavy and light chains?

Fab portion

Does the Fc portion of an antibody contain heavy or light chains?

Heavy chains

Every IgG antibody has the same ___________ region but not the same _________ region.

A) Fc, Fab

B) Fab, Fc

A) Same Fc region, variable Fab region

Does the Fc or Fab region of an antibody bind to complement proteins to initiate the complement pathway?

Fc region

Which granulocytes are phagocytic? (Choose 2)

A) Neutrophils

B) Eosinophils

C) Basophils

A and B

What is the first leukocyte that arrives in a bacterial infection?

Neutrophil

Which of the following is an example of a non-specific immunity in the eye?

A) Blinking of the lids

B) Flushing of the tears

C) IgA found in the tears

D) Shedding of corneal epithelial cells

E) All of the above

E) All of the above

Which interferons can be used for the treatment of Hepatitis C and Kaposi's sarcoma?

A) Alpha

B) Beta

C) Gamma

A) Alpha

Which interferons can be used for the treatment of relapsing multiple sclerosis?

A) Alpha

B) Beta

C) Gamma

B) Beta

Which interferons can be used for the treatment of chronic granulomatous disease?

A) Alpha

B) Beta

C) Gamma

C) Gamma

Interferons provide a nonspecific resistance to ___________ infections.

A) Bacterial

B) Fungal

C) Viral

D) Parasitic

C) Viral

Which of the following is NOT true regarding NK cells?

A) They require an antigen presenting cell (APC)

B) They are non-specific lymphocytes

C) They can provide rapid response to a virus

D) They can provide rapid response to tumor cells

A (do not require APC)

Which of the following is NOT a major function of the complement pathway?

A) Direct lysis of bacteria

B) Opsonization

C) Chemotaxis of neutrophils and macrophages

D) Increase in vascular permeability

E) Stabilize the blood aqueous barrier

E

Does IgA found in tears activate the classical or alternative complement pathway?

Alternative pathway

Does IgG and IgM primarily activate the classical or alternative complement pathway?

Classical pathway

Are T cells or B cells primarily responsible for humoral immunity?

B cells

Do B lymphocytes or T lymphocytes secrete antibodies?

B lymphocytes (plasma cells)

Are T lymphocytes or B lymphocytes primarily associated with cellular immunity?

T lymphocytes

Are CD8 or CD4 T cells known as Killer T cells?

CD8

Are CD8 or CD4 T cells known as Helper T cells?

CD4

Do CD8 T cells bind to MHC 1 or MHC 2?

MHC 1

Do CD4 T cells bind to MHC 1 or MHC 2?

MHC 2

Are CD8 or CD4 T cells primarily attacked in HIV?

CD4 T cells

All nucleated cells in the body have which type of MHC 1 or MHC 2 receptors?

MHC 1

Do Antigen presenting cells primarily contain MHC 1 or MHC 2 receptors?

MHC 2

Which of the following is NOT considered a classical Antigen Presenting Cell (APC)?

A) Basophil

B) Macrophage

C) Dendritic cells

D) Langerhans cells

E) B cells

A) Basophil

Which of the following is considered a nonspecific lymphocyte?

A) Neutrophil

B) T cells

C) B cells

D) NK cells

D) NK cells

Which cell type is primarily responsible for the immune response in tissue transplant rejections?

A) CD4 T cells

B) B cells

C) CD8 T cells

D) Eosinophils

C) CD8 T cells

Which ocular medication inhibits T cell activation by inhibiting IL-2 production?

Restasis (cyclosporine)

Which antibody is the first to respond in an initial exposure?

IgM

Which antibody is the first to respond in a 2nd time exposure?

IgG

Which antibody can cross the placenta?

IgG

Which region of the eye is NOT considered to be immune privileged?

A) Cornea

B) Conjunctiva

C) Vitreous

D) Crystalline lens

B) Conjunctiva

Which immune cells are primarily involved in a type 4 hypersensitivity reaction?

CD8 T cells (Killer T cells)

Which HLA is associated with glaucomatocyclitic crisis?

HLA B54

Which conditions are associated with HLA B27?

UCRAP

Ulcerative colitis

Crohns

Reiter's arthritis

Ankylosing spondylitis

Psoriatic arthritis

A (+) ANA is most associated with which systemic condition?

A) Thyroid eye disease

B) SLE

C) Sarcoidosis

D) Rheumatoid arthritis

B) SLE