3.7 - BRUGIA MALAYI

Malayan's Filarial Worm

common name

man

final host

mosquito

intermediate host

Mansonia, Anopheles

vector for B. malayi

Macaques and leaf monkeys

reservoir host

upper lymphatic system

habitat

skin penetration

mode of transmission

L3-filariform larva

infective stage in man

microfilaria

infective stage in mosquito

microfilaria

diagnostic stage

irregularly spaced

nuclei

present

sheath

(yes) Giemsa

staining affinity

two

terminal nuclei

2:1

cephalic space LW

kinky

appearance

nocturnal/subperiodic

periodicity

200-275um

adult female length

Pathogenesis

- Lymphadenitis
- Lymphangitis
- Elephantiasis
- Tropical Pulmonary Eosinophilia
- Chyluria
- Hydrocele
- Meyers and Kouwenaar Syndrome
- Sowda

Lymphedema

Elephantiasis
Repeated ADLA episodes

Tropical Pulmonary Eosinophilia

- persistent hypereosinophilia
- concentration technique
- lung biopsy

>3000/uL of blood

persistent hypereosinophilia

negative result

concentration technique

positive microfilaria

lung biopsy

- Diethylcarbamazine (DEC)
- DEC + Ivermectin
- Albendazole

treatment

Aedes poecilus

mosquito vector in the PH

Anopheles minimus var. flavirostris

mosquito vector in Sulu and Palawan