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Last updated 2:39 PM on 10/3/26
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833 Terms

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Principles of Medication Administration

  • Right Patient: Verify the patient’s identity using at least two identifiers (e.g., full name and date of birth) and cross-check their wristband. [1, 2]

  • Right Drug: Double-check the medication label against the physician’s order at least three times (when retrieving, preparing, and putting the drug away). [1, 2]

  • Right Dose: Confirm that the dosage amount is appropriate for the patient, paying special attention to calculations and high-alert medications (like insulin or heparin) which require an independent double-check by another professional. [1, 2]

  • Right Route: Ensure the medication is delivered via the specified path (e.g., oral, intravenous, intramuscular, subcutaneous, or topical) as different routes alter absorption and onset speeds. [1, 2]

  • Right Time:


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Nurse responsibility with medications

The nurse must know all aspects of the drug being administered and appropriate nursing parameters.

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Right to Refuse

The patient has the right to refuse any medication.

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Nursing action when a patient refuses medication

Explain risks of refusing, reinforce why it is prescribed, notify the HCP, and document.

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Patient's Right to Education

The patient has the right to accurate and thorough information about medications.

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Medication education should include

Medication name, purpose, action, side effects, dietary restrictions, and labs requiring monitoring.

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Drug information resources

USP-NF, PDR, pharmacology texts, nursing drug references, journals, electronic formularies, and pharmacists.

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FDA

Food and Drug Administration; involved in establishing and regulating drug standards.

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ISMP

Institute for Safe Medication Practices.

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DEA

Drug Enforcement Administration; regulates controlled substances.

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U.S. drug legislation

Sets official drug standards and defines prescription drugs.

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Nurse Practice Acts

Laws that regulate nursing practice, including medication administration.

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Institutional Policies

Facility-specific rules and procedures nurses must follow when administering medications.

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Drug Research

A complex process that follows ethical principles and informed consent.

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Informed Consent

Required ethical component of drug research.

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Drug Trials

Research trials must be conducted with integrity.

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New Drug Development

Occurs through four phases according to the pharmacology lecture.

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Over-the-Counter Medication (OTC)

Medication that can be obtained without a prescription.

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Prescription Medication

Medication that requires an authorized prescription.

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Herbs/Botanicals

Plant-based substances that may be used for health purposes.

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Pharmaceutical Classification

Classifies drugs by mechanism of action, physiologic effect, and chemical structure.

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Therapeutic Classification

Classifies drugs according to clinical indication or therapeutic action.

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Examples of Therapeutic Classes

Analgesic, antibiotic, and antihypertensive.

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Chemical Name

Identifies a drug's atomic and molecular structure.

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Generic Name

Name assigned by the manufacturer that first develops the drug and derived from its chemical name.

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Trade Name

Brand name copyrighted by the company selling the drug.

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Medication Prescription: Patient Information

Must include the patient's full name; some locations also require an address.

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Medication Prescription: Date and Time

Must include the date and time the order was written.

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Medication Prescription: Medication

Must identify the medication being prescribed.

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Medication Prescription: Dosage

Must state how much medication is to be administered.

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Medication Prescription: Frequency

Must state how often the medication should be administered.

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Medication Prescription: Route

Must state how the medication is administered.

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Medication Prescription: Prescriber

Must include the prescriber's printed name, signature, credentials, and required registration information.

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Controlled Substance

A medication regulated by the DEA.

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Controlled Substance Nursing Responsibility

Account for all narcotics on the unit.

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Medication Waste

Narcotic medication that is discarded or wasted must be countersigned according to policy.

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Narcotic Counts

Nurses perform narcotic counts according to facility policy.

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Controlled Medication Security

Only authorized individuals should have access to controlled-substance systems.

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Medication Error Contributing Factors

Poor communication, poor medication storage, heavy workload, interruptions, and distractions.

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Incident/Occurrence Report

A report associated with medication errors and safety events.

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Preventing Medication Errors

Arrive rested and undistracted and follow medication-administration rights.

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Preventing Dose Errors

Calculate doses carefully and double-check when required with another RN.

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Look-Alike/Sound-Alike Drug Safety

Watch for medications with similar names.

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Patient Identification Safety

Be cautious when patients have the same last name.

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Unfamiliar Medication Orders

Clarify unfamiliar medication names and dosages.

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Illegible Medication Orders

Clarify illegible orders before administering the medication.

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Medication Abbreviations

Avoid unsafe abbreviations when communicating medication orders.

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Medication Resources

Know and use available medication-information resources.

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Medication Order Changes

Keep up with changes in medication orders.

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Pharmaceutic Phase

The phase in which a medication must dissolve into solution before it can be absorbed.

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Tablets

Tablets are not 100% active drug.

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Drug Dissolution

Drugs generally need to be in solution before they can be absorbed.

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GI Fluids

Most medications disintegrate and absorb faster in acidic fluids.

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Food and Drug Absorption

Food in the GI tract may interfere with or enhance drug dissolution and absorption.

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Pharmacokinetics

The effect the body has on a drug.

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Four Pharmacokinetic Processes

Absorption, distribution, metabolism, and excretion.

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Pharmacodynamics

The effect a drug has on the body.

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Absorption

Movement of a drug into the bloodstream.

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Critical Concentration

Amount of medication needed to produce a therapeutic effect.

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Loading Dose

A dose given when a medication effect is needed quickly.

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Factors Affecting Absorption

Route, lipid solubility, pH, blood flow, administration site conditions, and dosage.

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Distribution

Transport of a drug to body tissues and organs.

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Factors Affecting Distribution

Local blood flow, membrane permeability, protein binding, blood-brain barrier, placenta, and breast milk.

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Metabolism/Biotransformation

Chemical conversion of a drug in the body.

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Factors Affecting Metabolism

Liver function, health or disease status, first-pass effect, and drug half-life.

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First-Pass Effect

A medication may pass through the liver before reaching systemic circulation.

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Excretion

Removal of a drug from the body.

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Factors Affecting Excretion

Function of the kidneys, liver, lungs, exocrine glands, and creatinine clearance/GFR.

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Creatinine Clearance/Glomerular Filtration Rate

Measurements related to kidney function that influence medication excretion.

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Lifespan Factors Affecting Medications

Age, weight, gender, pregnancy, genetics, and cultural factors.

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Therapeutic Range

the blood concentration or dosage of a medicine that treats a condition safely without causing harm

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Trough Level

the lowest concentration of a medication in a patient's bloodstream, measured right before the next scheduled dose

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Half-Life

the time it takes for the concentration of that medication in your bloodstream or body to reduce by 50%

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Receptor Theory

Explains drug activity through interaction with receptor sites.

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Agonist

Interacts with receptor sites to cause activity similar to naturally occurring chemicals.

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Agonist Example

The lecture uses insulin replacement as an example.

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Antagonist/Inhibitor

Drug interaction concept involving blocking or inhibiting activity at receptor sites.

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Antagonistic Interaction

happens when two or more drugs combine and the total effect is less than the sum of their individual effects

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Synergistic Interaction

occurs when two or more substances, agents, or factors combine to produce an overall effect that is greater than the sum of their individual effects working alone

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Drug Incompatibility

a physical or chemical reaction that happens in vitro (outside the body) when two or more drugs or solutions are mixed together in a syringe, IV bag, or tubing before administration

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Adverse Drug Effects Include

Primary actions, secondary actions, hypersensitivity, allergic reactions, and toxic effects.

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Side Effects

unintended secondary reactions that happen along with the main therapeutic benefits of a drug

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Medication Indications

Preventative, diagnostic, or treatment purposes.

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Factors Influencing Drug Choice

Age, disease, condition, medical history, side effects, expected results, allergies, and availability.

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Medication Teaching: Administration

Teach the patient proper techniques for administering the medication.

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Medication Teaching: Frequency

Teach how frequently and for how long the medication should be taken.

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Medication Teaching: Dose Changes

Patients should not change medication doses without consulting the healthcare provider.

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Medication Sharing

Patients should not share medications.

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Medication Storage

Teach patients how medications should be stored.

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Therapeutic Communication

Purposeful professional communication used within the nurse-patient relationship.

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Forms of Communication

Verbal and nonverbal communication.

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Verbal Communication

One major form of communication identified in the lecture.

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Nonverbal Communication

Communication through nonverbal cues such as posture, facial expression, and gestures.

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Communication Methods Used by Nurses

Auditory, visual, and kinesthetic methods.

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Communication Technologies

Electronic communication, social media, email, text messaging, telehealth, and telemedicine.

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Factors Influencing Communication

Developmental level, culture, roles, space, health state, values, and environment.

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Developmental Level

Factor that can influence how a person communicates.

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Sociocultural Differences

Cultural and social differences can influence communication.

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Roles and Responsibilities

A person's role and responsibilities can influence communication.

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Space and Territoriality

Personal space and territorial needs can influence communication.