Pharm II: Drugs for Men's Health

successful erection requires an adequate release of

nitric oxide

which medication is priapism more common with?

alprostadil

Those on ______ should not take PDE5 inhibitors.

nitrates

oral phosphodiesterase type 5 inhibitors

sildenafil

vardenafil

tadalafil

absorption of ______ is inhibited in presence of food

sildanefil

onset of action & duration of sildenafil and vardenafil

onset: 30-120 mins

duration: 4 hours

Tadalafil onset of action and duration

onset of action: 15 mins

duration: 36 hours

aside from ED, sildenafil and tadalafil can also treat

pulmonary hypertension

tadalafil can also treat

BPH

phosphodiesterase inhibitors adverse reactions

flushing, visual disturbances, epistaxis, dyspepsia, headache

Phosphodiesterase Inhibitors can also interact with

antihypertensives

Phosphodiesterase Inhibitors contraindications

nitroglycerin, isosorbide mononitrate, isosorbide dinitrate

sickle cell, myeloma, leukemia

injectable prostaglandins

Alprostadil

Alprostadil is a synthetic form of

prostaglandin E1

Alprostadil onset of action & duration

onset - 10 mins

duration- 1 hour

most common adverse reaction of Alprostadil

penile pain

Alprostadil contraindications

penile deformity

penile implant

sickle cell, leukemia, myeloma

drugs that can worsen BPH

first-gen antihistamines

decongestants

narcotics

anticholinergic meds

what 2 drugs, when used together, is more effective in treating BPH than using either drug alone?

finasteride and doxazosin

nonselective alpha blockers

doxazosin

prazosin

terazosin

selective alpha blockers

Tamsulosin

Alfuzosin

Prazosin can also be used to treat

nightmares

alpha-1 blockers adverse reactions

orthostatic hypotension, rhinitis, decreased libido, ejaculation failure, headache, dizziness

alpha-1 blockers contraindications

concurrent use with phosphodiesterase inhibitors

5-alpha reductase inhibitors

Dutasteride

Finasteride

5-alpha reductase inhibitors clinical uses

BPH

male pattern baldness

PCOS

prostate cancer

HRT for transgender therapy (male to female)

5-alpha reductase inhibitors adverse reactions

impotence/ED, decreased libido

5-alpha reductase inhibitors interactions

ketoconazole, St Johns wort

5-alpha reductase inhibitors contraindications

pregnancy

why is finasteride contraindicated in pregnancy?

can produce abnormalities in genitalia of male offspring

what is a problem with taking 5-alpha reductase inhibitors?

can lower PSA levels (which are used to screen for prostate cancer)

exogenous testosterone adverse reactions

MI, CVA, DVT/PE, male pattern baldness, gynecomastia, oligozoospermia, priapism, polycythemia, aggressive behavior

exogenous testosterone contraindications

breast cancer in men

prostate cancer

pregnancy

testosterone is a controlled substance - which schedule?

schedule III

what medications are used to treat male pattern baldness

finasteride

minoxidil

when screening men on finasteride for prostate cancer, clinicians should

double the patients PSA levels

new hair is lost within _____ when treatment is discontinued

4-6 months

treatment of epididymitis and orchitis

ceftriaxone and doxy

treatment for prostatitis

bactrim or cipro