PPT1 Enterotoxigenic E. coli (ETEC)

What is the ETEC?

Enterotoxigenic E. coli

Which TYPE of E. coli is the primary cause of traveler’s diarrhea?

ETEC / EnteroToxigenic E Coli

What is the infective dose of ETEC type?

10^6 - 10^10

What is the common route of exposure for EnteroToxigenic E. Coli?

Contaminated food + water

Which group of people does the Enterotoxigenic E coli (ETEC) affect?

ALL AGES

Infants, children, adults

Where do the ETEC organisms attach?

INTESTINE

In the intestine, what does the release of Enterotoxins by ETEC cause?

FLUID secretion → WATERY diarrhea

What are the two types of Enterotoxins that ETEC has?

LT and ST

Which ETEC enterotoxin increases cAMP?

LT enterotoxin

Which ETEC enterotoxin increases Adenylate cyclase activity?

LT enterotoxin

Which ETEC enterotoxin increases cGMP?

ST enterotoxin

What do the two enterotoxins of ETEC cause?

Increased electrolyte secretion → reduced absorption → water enters intestinal lumen → WATERY DIARRHEA

Which subunit of the LT enterotoxin BINDS to GM1 ganglioside on intestinal cells?

B subunit

Which subunit of the LT enterotoxin ACTIVATES Gs signaling?

A subunit

Which enterotoxin of ETEC causes increased Guanylate cyclase activity?

ST