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Hypothalamus
Structure responsible for coordinating the activity of both the anterior and posterior pituitary.
Distinction between Anterior and Posterior Pituitary
The anterior pituitary produces its own hormones, while the posterior pituitary stores and releases hormones produced by the hypothalamus.
ACTH
A hormone released by the anterior pituitary that acts on the adrenal gland.
HPA-axis pathway
The sequence is Hypothalamus → CRH → anterior pituitary → ACTH → adrenal cortex.
Stress
A major physiological stimulus that activates the HPA axis.
Circadian clock influence on HPA axis
Provides timing-related input into the stress-response system.
CRH
A hormone produced by the hypothalamus in response to stress that stimulates the anterior pituitary.
Glucocorticoids
Hormones ultimately produced by the adrenal gland in response to ACTH.
Adrenal medulla location
The center of the adrenal gland.
Catecholamines
Hormones primarily produced by the adrenal medulla.
Zona fasciculata
The adrenal cortical zone that produces glucocorticoids.
Androgens
The primary product of the zona reticularis.
Mineralocorticoid
A category of hormones that includes aldosterone.
Zona reticularis
The adrenal zone that primarily produces androgens.
Sympathetic activity during stress
Increased sympathetic activity and increased epinephrine are expected responses.
Vasopressin
Hormone that promotes water retention and is also known as ADH.
Vasopressin production
Produced by the hypothalamus and stored/released by the posterior pituitary.
Water retention
The primary function of vasopressin.
Vasopressin's role in fluid balance
Regulates the relationship between water and dissolved substances such as salts.
Vasopressin receptor action
Promotes insertion of AQP2 aquaporin channels in the nephron.
Increased blood volume effect
Increased water reabsorption can lead to increased blood volume and blood pressure.
AQP2 and AQP3 comparison
AQP2 is regulated by vasopressin, while AQP3 is not.
Insulin response to food intake
Generally secreted in response to food intake, particularly carbohydrate availability.
Glucagon
Hormone that access glucose reserves when blood glucose is low.
Insulin and glucagon functions
Complementary regulators that act in opposing directions to help regulate blood glucose.
Epinephrine
Associated with the sympathetic fight-or-flight response and mobilization of fuel reserves.
High-carbohydrate meal response
Blood glucose rises, insulin rises, and glucagon decreases.
Amino acids rise after protein meal
Leads to insulin increase without a major rise in blood glucose.
Neuronal relationship
Determined by the behavior of the presynaptic neuron and the relationship between the neurons.
Rigor mortis cause
Occurs primarily because ATP is unavailable for myosin detachment.
Concentric contraction
A contraction in which the muscle produces force while shortening.
Neuromuscular junction
Connection between a motor neuron and a muscle fiber.
Motor end plate
Specialized region of the muscle cell membrane at the neuromuscular junction.