ASMs MedChem - Guo

Learning Objectives

1. Match drug names to structures

2. Know functional groups within representative drugs

3. Understand SAR of representative drugs

4. Know key features of representative drugs

no need to memorize detailed structures

All ASMs pertinent to this lecture

1. Works on GABAa receptors

   1. Barbiturates

   2. BZDs

   3. Felbamate

   4. Ganaxolone

   5. Topiramate

2. Works on Sodium Channels

   1. Hydantoin

   2. CBZ

   3. Lamotrigine

   4. Lacosamide

   5. VPA

3. Works on Calcium channels

   1. Ethosuximide

   2. Pregabalin

   3. Gabapentin

   4. CBD

   5. CB receptors

4. Works on potassium channels

   1. Retigabine

   2. Ezogabine

5. GABA transaminase

   1. Vigabatrin

6. NMDA/σ1R/5HT2A/C Complex

   1. Fenfluramine

Barbiturates Structure/functional groups

Benzodiazepines general structure

Felbamate Structure/functional groups

Ganaxolone Structure

Topiramate Structure

Hydantoins Structure/metabolism

Fosphenytoin Structure

Ethosuximide Structure

Carbamazepine and Oxcarbazepine structures

Lamotrigine Structure

Lacosamide Structure

Valproic Acid structure

Gabapentin Structure

Pregabalin structure

Vigabatrin structure

Delta-1 and Delta-2 CBD structures

General CBD structure

Rufinamade structure

Zonisamide structure

Levetiracetam Structure

Brivaracetam Structure

Tiagabine structure

Fenfluramine structure