class 20 VDJ

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4 Terms

1
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how are heavy chain genes made up

V - variable segment

D - diversity segment

J - joining segment

2
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how are light chain genes made up

only V and J

3
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RSS motifs

adjacent to gene sequences that can be recombined

proteins (RAG1 and 2) bind to the RSS motifs flanking V or J segments.

RAGs bring them toegether to be recombined and cleave, creating a hairpin and DSB.

protein complex cleaves hairpin.

4
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what do RAGs do

proteins (RAG1 and 2) bind to the RSS motifs flanking V or J segments.

RAGs bring them toegether to be recombined and cleave, creating a hairpin and DSB.

protein complex cleaves hairpin.