blood bank: transfusion support for selected patients

hemophilia A patients have a defect in

factor VIII

which hemophilia is X linked and therefore mostly affects males

hemophilia A

hemophilia B is a defect in

factor IX

one dosage of factor VIII will increase factor activity by

2%

one dosage of factor IX will increase factor activity by

1%

what are inhibitors

antibodies to factor VIII and factor IX

sickle cell mutation

glutamic acid is replaced by valine on position 6

what is ischemia

lack of oxygen to tissues

in critical cases of SCD, what therapy is used

exchange transfusion

what blood component is used to reduce the possibility of febrile non hemolytic transfusion reactions

leukoreduced packed RBCs

what is an HPC

hematopoietic progenitor cell, stem cells that will divide and eventually develop into RBCs, WBCs, and platelets

for a stem cell transplant, the donor must be

HLA compatible

all blood units to be transfused to HPC transplant patients shoudl be ___

irradiated

what does irradiation do

it kills T cells in the donor unit that might mount an immune response to the patient

granulocyte transfusions are most effective against ___ infections and less effective against ___ infections

fungal, bacterial

what is passenger lymphocyte syndrome

lymphocytes in a transplanted organ produce anti-A or anti-B and cause mild hemolysis

solid organs SHOULD be

HLA compatible

vitamin K is produced in the

liver

which factors are vitamin K dependent

II, VII, IX, and X

fibrinogen is produced in the

liver

FFP is given to patients with liver disease to correct

coagulation deficiencies

patients who cannot receive FFP are administered

factor VII

erythropoietin is produced in the

kidneys

what is the half life of factor VIII

12 hours

a physician orders an exchange transfusion for a patient with sickle cell disease. what are the anticipated benefits of this type of transfusion

decreased percentage of sickle cells

which technique reduces the risk of hyperhemolysis in sickle cell anemia patients

phenotype matched RBCs

allogeneic HPC transplants require donor and recipient to be

HLA compatible

TA-GVHD is preventable with which of the following methods

irradiation

RBC hemolysis that occurs approximately 7-14 days after transplant of an organ with minor ABO incompatibility is termed

passenger lymphocyte syndrome

which coagulation factor has the shortest half life

factor VII

the process that is used to remove circulating antibody that is causing disease is called

plasmapheresis