FINALS: Intro to Malignancies

A malignancy involving blood-forming tissues, often with abnormal leukocytes

Which statement best describes leukemia?

Presence of many immature cells and rapid symptom development

Which finding is more characteristic of acute leukemia than chronic leukemia?

Myeloma

Which malignancy primarily involves plasma cells in the bone marrow and may produce abnormal proteins?

Reed-Sternberg cell

Which cell is the hallmark of Hodgkin lymphoma?

French-American-British (FAB) classification

Which classification system divides Acute Myeloid Leukemia (AML) into M0–M7?

Morphology, cytochemistry, immunophenotype, genetics, and clinical features

Which features are considered in the World Health Organization (WHO) classification of hematologic malignancies?

Replace normal marrow elements and may be associated with bleeding

Acute leukemia may cause anemia because leukemic blasts:

It may be elevated, normal, or decreased

Which statement about the total leukocyte count in acute leukemia is correct?

Longer symptom duration and mostly mature cell forms

Which is a characteristic of chronic leukemia compared with acute leukemia?

Lymphoma

Which malignancy generally begins in the lymphatic system, particularly the lymph nodes?

Maturation block and acquired genetic alterations in hematopoietic progenitor cells

Acute Myeloid Leukemia (AML) is characterized by:

M0

Which FAB subtype of AML is characterized by undifferentiated blasts or minimal differentiation?

Blasts and promyelocytes predominate without further maturation

In FAB M1 AML, which feature is expected?

M2

Which FAB subtype is known as AML with maturation?

Acute promyelocytic leukemia (APL)

FAB M3 AML is also known as:

t(15;17)

Which genetic abnormality is associated with Acute Promyelocytic Leukemia (APL)?

M4

Which FAB subtype involves both myeloid and monocytic cells?

Monocytic

FAB M5 AML is classified as:

Abnormal proliferation of erythroid and granulocytic precursors

Which statement describes FAB M6 AML, or erythroleukemia?

M7

Which FAB subtype is acute megakaryoblastic leukemia?

AML with certain genetic abnormalities

Which WHO category includes AML with t(8;21), inv(16), and t(9;11)?

Acute monoblastic/monocytic leukemia

Which is included under AML, not otherwise specified in the WHO classification?

M5

Which FAB subtype is associated with Schilling's type monocytic leukemia?

M6

Which FAB subtype is associated with Di Guglielmo syndrome?

Megakaryoblasts with a high nuclear-to-cytoplasmic ratio and pale, agranular cytoplasm

Which finding is characteristic of FAB M7 AML?