Uses and MOA of each drug classes

K channel blocker = hyperpolarization = no exocytosis of insulin

MOA of Sulfonylureas

Glucose uptake

Mechanism of action of Insulin

• Activate protein Kinase = Glucose utilisation

Mechanism of action of Biguanides

PPAR-Gamma agonist = glucose utilisation and FA utilization

Mechanism of action of Thiazolidinediones

Inhibits a glucosidase

Mechanism of action a glucosidase inhibitors

• GLP 1 AGONIST

Mechanism of action of Incretin mimetics

• Enhance incretic by inhibiting DPP IV

MOA of DPP IV inhibitors

Inhibits Reabsorption of glucose in PCT

MOA of SGLT2

• Decrease glucagon secretion

• Decrease GET

Mechanism of action of Amylin analogues

DM1

Insulin is used to treat what type of dm

• DM2

• Post-prandial hypoglycemia

Sulfonylureas are used to treat what type of DM

• 1st line for type 1 diabetes

• Mgt of prediabetes

Biguanides are used for what type of diabetes

Type 2 diabetes

Thiazolidinediones are used for what type of diabetes

Type 2 diabetes

What type of diabetes is a glucosidase inhibitors used for

• Anorexia

• Chronic wt management

Used of incretin based drugs

Type 1 and 2 diabetes

Incretin mimetics are used for which types of diabetes

Monotherapy or w/ Metformin or w/ DPP IV Inhibitor

SGLT2 Inhibitors are used as

Type 1 and type 2 diabetes

Amylin analogues are used for what type of diabetes

Amylin analogues

The only non-insulin injectable

• Hypoglycemia

• Lipodystrophy

• Weight gain

• Allergy

Toxic effects of Insulin

• Weight gain

• Hypoglycemia

• Disulfiram like reaction (flushing)

Toxic effects of sulfonylureas

• Weight loss

• Diarrhea

• Lactic acidosis

Toxic effects of Biguanides

• Cardiotoxicity

• Hepatoxicity

Toxic effects of Thiazolidinediones

• Hypoglycemia

• Flatulence

Toxic effects of a glucosidase inhibitors

• Enhances insulin secretion

• Decreases glucagon

• Delay gastric emptying time

Effects of incretin based drugs

• Wt loss

• Hypoglycemia

• Nausea and vomitting

Toxic effects of DPP IV inhibitors

• Hypoglycemia

• Wt loss

• Increased risk of UTI

Toxic effects of SGLT2

• Hypoglycemia

• Nausea and vomiting

• Wt loss

Toxic effects of amylin analogue