Side effects

Amantadine

CNS and GI disturbances

Rimantadine

Fewer CNS effects than amantadine

Tecovirimat

Mild headache and nausea

Oseltamivir phosphate

Mild nausea and vomiting, especially during the first two days

Enfuvirtide

Injection-site pain, erythema (redness), pruritus (itching), and insomnia

Maraviroc

Allergic reactions and potential liver toxicity

Valacyclovir

Nausea, headache, vomiting, and anorexia

Famciclovir

Headache and GI effects

Cidofovir

Nephrotoxicity

Zidovudine

Bone marrow toxicity

Didanosine

Peripheral neuropathy and pancreatitis

Stavudine

Peripheral neuropathy; pain or numbness in hands and feet

Lamivudine

Peripheral neuropathy and GI effects

Abacavir

Headache and GI effects

Nevirapine

Hepatotoxicity and skin rash

Delavirdine

Skin rash

Efavirenz

Rash

Saquinavir mesylate

GI effects

Ritonavir

GI and CNS effects

Indinavir sulfate

GI effects

Nelfinavir mesylate

GI effects

Tipranavir

Severe intracranial hemorrhage, hepatitis, and diabetes

Nystatin

Systemic use is toxic

Amphotericin B

Severe nephrotoxicity

Ketoconazole

Potential for serious drug interactions

Itraconazole

Drug interactions; increased rhabdomyolysis risk with lovastatin or simvastatin

Fluconazole

Can affect warfarin and phenytoin metabolism

Voriconazole

Inhibits CYP2C19, CYP2C9, and CYP3A4

Posaconazole

CYP3A4 inhibition and potential drug interactions

Terbinafine

Severe liver toxicity; avoid alcohol

Artemisinin

Hypersensitivity, GI effects, dizziness, and elevated liver enzymes

Lumefantrine

Hypersensitivity, GI effects, dizziness, and elevated liver enzymes listed for combination therapy

Artemether/lumefantrine (Coartem)

Hypersensitivity, GI effects, dizziness, and elevated liver enzyme