Ceutics Quiz 4

Targeted drug delivery systems are designed to:

D. All of the above

Which of the following problems is associated with targeted delivery systems:

I. Immune reactions may be developed against the drug encapsulated

II. Target tissue heterogeneity

III. Interference with the receptors expressed in peripheral (nontarget) tissues

I, II, and III

Use of antibody-drug conjugate to target a solid tumor may be classified as:

Active targeting

Passive targeting of nanoparticles to the tumor tissue following intravenous injection is mediated by:

EPR effect

Which drug targeting strategy utilizes the natural biodistribution of colloidal particles to accumulate in the reticuloendothelial system (RES), making it suitable for treating conditions like leishmaniasis?

Passive targeting

Abraxane® is made by

Albumin-bound paclitaxel

Problems associated with Antibody-based targeted delivery systems for cancer are:

A. Target antigen expression in tumor as well as normal cells

B. Rapid clearance of antibody coated carriers

C. Down regulation of receptors on the target cells

D. Tumor heterogeneity in receptor expression

All choices

The following about antibody-directed enzyme prodrug therapy (ADEPT) are correct, EXCEPT:

The drug should have long half-life

Which enzyme is involved in the conversion of Dexamethasone-21-β-Glucoside to its parent drug, dexamethasone?

Glucosidase

Kadcyla (trastuzumab-DM1) is an immunoconjugate approved for metastatic breast cancer. It is a ___

Humanized antibody

Which of the following will be the most efficient for targeting?

Liposome-PEG-antibody

Which of the following is CORRECT about chemical delivery system?

All of the above

Which of the following is a limitation of resealed erythrocytes as drug carriers?

Heterogeneity in the life span of RBC population

The following reasons for the use of cholesterol in liposome preparation are true, EXCEPT:

It increases the release rate of entrapped drugs

Which of the following about active loading of liposomes is NOT correct?

High leakage of entrapped drugs is a common problem with active loading

Which of the following liposomes may be used for sustained drug delivery?

MLV

Which liposome is prepared by grafting polymer at the surface to increase their circulation time in the blood?

Stealth liposomes

Which of the following about antibody-drug conjugates is correct?

Overall tumor targeting with whole Ab was better than Ab fragment

Tumor vascular targeting is advantageous over tumor cell targeting because

Vascular targeting is applicable to any type of solid tumor

Myocet® is a liposomal product of

Doxorubicin

DepoDur® is a liposomal product of

Morphine