Chapter 4: PSY-432 (1267-11239) PSYCHOPHYSIOLOGY DRUGS AND BEHVR (Fall 2026 M16) 002

_______ is an example of an ionotropic receptor.

 

Dopamine

 

Anandamide

 

GABA

 

Opioids

GABA

The blood–brain barrier (BBB) is the strongest in the

 

area postrema.

 

posterior pituitary gland.

 

frontal lobe.

 

hypothalamus.

frontal lobe.

The first-pass effect occurs with which of the following routes of administration?

 

Inhalation

 

Transdermal

 

Oral

 

IV

Oral

__________ is the most important organ for metabolism of drugs.

 

Bladder

 

Esophagus

 

Kidney

 

Liver

Liver

Intravenous injection gets the drug to the brain fastest.

 

False

 

True

False

Which is true about first-order kinetics?

 

The rate of metabolism is independent of the concentration of the drug.

 

Alcohol is metabolized by first-order kinetics.

 

The metabolism rate is directly proportional to the concentration of a drug.

 

Drugs metabolized by the liver undergo first-order kinetics; drugs metabolized by the kidney undergo zero-order kinetics.

The metabolism rate is directly proportional to the concentration of a drug.

An antagonist is a drug that

 

makes you sleep.

 

binds to a receptor and produces an excitatory response.

 

binds to a receptor without producing an effect except to block other substances from the receptor.

 

increases the reuptake of the neurotransmitter into the presynaptic neuron.

binds to a receptor without producing an effect except to block other substances from the receptor.

_______ is most subject to the first-pass effect.

 

Oral ingestion (pills)

 

Vaping

 

Patches

 

Sublingual

Oral ingestion (pills)

A substance that binds to a receptor and initiates a response opposite to that of the agonist is called a(n)

 

opponent.

 

negative allosteric modulator.

 

antagonist.

 

inverse agonist.

inverse agonist.

An agonist binds to a receptor without producing an effect except to block other substances from the receptor.

 

True

 

False

False

If two drugs are taken concurrently and are both metabolized by the CYP450 enzyme system, large amounts of drug A will increase the metabolism of drug B.

 

False

 

True

False

Which of the following is an example of behavioral tolerance?

 

When a chronic, heavy drinker is tolerant to Xanax, even though they've never taken Xanax before

 

When a chronic, heavy drinker produces more liver enzymes that metabolize alcohol

 

When a person who smokes marijuana regularly can handle themselves high better than they could the first time they got high

 

When someone who regularly uses morphine has a decrease in the number of opioid receptors

When a person who smokes marijuana regularly can handle themselves high better than they could the first time they got high

Which is true about cellular tolerance?

 

Tolerance that occurs when the body metabolizes a drug faster by increasing production of liver enzymes

 

There is no such thing as cellular tonerance

 

Tolerance that occurs when a person learns to handle themselves while on a drug

 

Tolerance that develops when the neurons adapt to the presence of a drug by changing the receptor density

Tolerance that develops when the neurons adapt to the presence of a drug by changing the receptor density

Which of the following is not a drug depot?

 

Muscle

 

The brain

 

Fat

 

Plasma proteins

 

The brain

What does line A represent?

 

Full agonist

 

Inverse agonist

 

Neutral antagonist

 

Partial agonist

Full agonist

Which route of administration transports a drug to the brain the fastest?

 

Rectal

 

Oral

 

Transdermal

 

Inhalation

Inhalation

Which of the following affects drug absorption?

 

All answers are true

 

The pH of the drug

 

The drug's route of administration

 

Whether it is fat soluble or water soluble

All answers are true

Which of the following does not affect the metabolism of drugs?

 

Age

 

Mood or expectations

 

Other drugs or foods taken at the same time

 

Genetic factors

Mood or expectations

Which lettered line represents a neutral antagonist?

 

B

 

D

 

C

 

A

C

What is the route of administration for the birth control patch?

 

IV

 

Oral

 

Inhalation

 

Transdermal

Transdermal