Mycvir midterm - Exanthema

Exanthem

Widespread skin rash accompanying systemic illness caused by viral toxins, direct skin damage, or immune response.

Stensen's Duct

Salivary gland duct swabbed for Mumps virus isolation from 9 days before to 8 days after parotitis onset.

Vero or LLC-MK2

Optimal cell lines used for successful shell vial culture isolation of Mumps virus.

Parotitis (painful parotid gland swelling)

Classic clinical manifestation of Mumps virus infection.

Rounded and Multinucleated Giant Cells

Characteristic cytopathic effect (CPE) produced by Mumps virus in traditional cell culture.

Orchitis

Severe testicular complication following Mumps infection in post-pubertal males.

Morbillivirus

Genus classification of Rubeola (Measles) virus.

Koplik Spots

Pathognomonic bluish-white spots with a red halo on the buccal mucosa seen in Measles.

Primary Monkey Kidney (PMK)

Primary cell line used for Rubeola virus culture resulting in spindle-shaped or multinucleated cells.

Guillain-Barré Syndrome (GBS)

Rare autoimmune complication following measles causing progressive peripheral nerve paralysis.

Aerosol Transmission

Primary route of transmission for Rubeola (Measles) virus.

Rubivirus

Genus of Rubella virus within the Togaviridae family.

Only Non-Arthropod-Borne Togavirus

Unique epidemiological property of Rubella virus compared to other Togaviridae.

Postauricular and Suboccipital Lymphadenopathy

Characteristic lymph node enlargement associated with Rubella (German Measles) infection.

Palms and Soles

Anatomical locations characteristically spared by the Rubella rash.

Congenital Rubella Syndrome (CRS)

Devastating outcome of 1st trimester intrauterine Rubella infection resulting in cataracts, deafness, and heart defects.

Group A Coxsackievirus

Picornavirus group responsible for Herpangina and Hand-Foot-and-Mouth Disease.

Group B Coxsackievirus

Picornavirus group responsible for pleurodynia, myocarditis, pericarditis, and viral heart disease.

Coxsackievirus A16 and Enterovirus 71

The two most common causative viral agents of Hand-Foot-and-Mouth Disease (HFMD).

Coxsackievirus B4

Specific enterovirus strain associated with the development of early-onset diabetes.

Coxsackievirus A24

Specific enterovirus strain responsible for epidemic acute hemorrhagic conjunctivitis.

Suckling (Newborn) Mice

In vivo animal host required for the laboratory isolation of Group A Coxsackievirus.

Coxsackie, New York

Geographical location in New York after which Coxsackievirus was named.

Smallest Non-Enveloped ssDNA Virus

Genomic classification of Parvovirus B19 among animal viruses.

Erythroid Progenitor Cells

Principal target cell lineage for Parvovirus B19 replication.

Blood Group P Antigen (Globoside)

Cellular membrane receptor utilized by Parvovirus B19 for host cell entry.

Fifth Disease (Erythema Infectiosum)

Childhood exanthem caused by Parvovirus B19 featuring a "slapped cheek" facial rash.

Hydrops Fetalis

Severe intra-uterine fetal complication resulting from Parvovirus B19 infection during pregnancy.

Transient Aplastic Crisis

Acute erythropoietic arrest complication of Parvovirus B19 in patients with underlying hemolytic disorders.

NAAT / Quantitative PCR

Primary, most sensitive laboratory diagnostic assay for detecting Parvovirus B19 DNA.

MMR Vaccine

Trivalent live-attenuated vaccine administered for protection against Measles, Mumps, and Rubella.