pda exam #3

tolbutamide

chlorpropamide

tolazamide

glimepiride

glipizide

glyburide

metformin

ciglitazone

rosiglitazone

pioglitazone

repaglinide

nateglinide

sitagliptin

saxaglitpin

linagliptin

alogliptin

canagliflozin

dapagliflozin

empagliflozin

ertugliflozin

sotagliflozin

bexagliflozin

orforglipron

which site of this drug undergoes metabolism?

carbon next to benzene

which site of this drug confers selectivity for SUR1?

lipophilic carbon chain

tolbutamide metabolism

chlorpropamide metabolism

chlorine circumvents hydroxylation, w and w-1 hydroxylation occurs slowly at propyl group (longer half life)

where is the major site of metabolism for this molecule?

benzylic hydroxylation AND hydroxylation at N ring (middle carbon)

metformin structures

1-hydroxypioglitazone

gibenclamide (sulfonylurea)

what is the major route of metabolism for nateglinide?

w-1 hydroxylation at carbon on end of structure

what are the metabolites of this compound?

phenanthrene

cyclopentane

cyclopentanoprehydropenanthrene

cholestane

cholesterol

pregnane

name this structure

11B, 17, 21 trihydroxy-pregn-4-ene-3,20-dione (cortisol)

name this structure

pregn-4-ene-3,20-dione (progesterone)

androstane

estrane

17B-hydroxyandrost-4-en-3-one (testosterone)

name this structure

estra-1,3,5(10)-triene-3,17B-diol

name this structure

cholesterol

pregnenolone

17a-hydroxypregnenolone

progesterone

17a-hydroxyprogesterone

21-hydroxyprogesterone

11-deoxycortisol

corticosterone

aldosterone

cortisone

hydrocortisone

cortisone

cortisol

aldosterone

aldosterone hemiacetal form

fluorometholone

6-methylprednisolone

alcometasone dipropionate

fludrocortisone

cortisone

hydrocortisone

prednisone

prednisolone

6-methylprednisolone

triamcinolone

dexamethasone

betamethasone

deflazacort

triamcinolone acetonide

desonide

alclometasone

prenicarbate

fluorometholone acetate

fluocinolone acetonide

fluandrenolide

desoximetasone

betamethasone

clocortolone pivalate

amcinonide

halcinonide

diflorasone diacetate

clobetasol proprionate

halobetasol proprionate

loteprednol etabonate