Learn: Antidepressant Drugs

What is a common suffix used for many generic named antidepressants?

-ine

What are the three neurotransmitters that almost all antidepressants affect? (Select all that apply.)

*Norepinephrine

*Dopamine

*Serotonin

What affect do selective serotonin reuptake inhibitors (SSRIs) have on neurotransmitters in the brain?

They increase serotonin levels

How does a selective serotonin reuptake inhibitor(SSRI) increase serotonin levels at the synaptic cleft?

Destroys the enzyme that breaks down serotonin​

Why is amitriptyline called a "tricyclic" antidepressant?

It works on the three main neurotransmitters

Where are serotonin receptors located? (Select all that apply.)

*Gastrointestinal tract

*Platelets

*Peripheral nervous system

*Blood vessels

Besides depression, for which other conditions are antidepressants are prescribed? (Select all that apply.)

*Panic disorder

*Insomnia

Which of the following foods are high in Tyramine?

*Pickles

*Parmesan cheese

*Home brew beer

What are some safety concerns that need monitoring after starting an antidepressant? (Select all that apply.)

*Depressive symptoms become worse

*They become hypertensive

*They become suicidal

What causes serotonin syndrome?

Another medication interacts causing increased serotonin in the brain

1. Tricyclic

2. Selective Serotonin Reuptake Inhibitor ​

3. Serotonin and norepinephrine Reuptake Inhibitor ​

4. MAO Inhibitor ​

5. Atypical (bupropion or Wellbutrin) ​

1. Increase- Increase- Increase

2. Increase- No change- No change

3. Increase- Increase- No change

4. Increase- Increase- Increase

5. No change- Increase- Increase

1. fluoxetine ​

2. selegiline ​

3. citalopram ​

4. ​amitriptyline ​

5. venlafaxine ​

6. duloxetine ​

7. escitalopram

8. nortriptyline ​

9. phenelzine ​

1.0. sertraline ​

1. Selective Serotonin Re-Uptake Inhibitor ​

2. MAO Inhibitor ​

3. Selective Serotonin Re-Uptake Inhibitor ​

4. Tri-Cyclic ​

5. Serotonin Norepinephrine Re-Uptake Inhibitor ​

6. Serotonin Norepinephrine Re-Uptake Inhibitor ​

7. Selective Serotonin Re-Uptake Inhibitor ​

8. Tri-Cyclic ​

9. MAO Inhibitor ​

10. Selective Serotonin Re-Uptake Inhibitor ​

A client has been experiencing some depressive symptoms. Last week she went to her healthcare provider and was diagnosed with major depressive disorder (MDD). She was started on sertraline. She now says that she feels like her depression is worse. Which of the following statements apply? (Select all that apply.)

*It can take 4 to 6 weeks for antidepressants to start working.​

*She should not stop taking the medication without consulting her provider.

*She should call her provider immediately and let them know about her worsening symptoms.

You are a pharmacy manager reviewing some of your customers recent medication purchases. Review the purchases below and identify which ones require a call to the patient or healthcare provider to warn about a possible interaction. (Select all that apply.)

*Andy Sullivan​

-Zoloft ​

-venlafaxine

Joseph Johnson​

-Prozac​

-fluvoxamine

Randy Bremmly​

-St. John's Wort​

-fluoxetine

Judy is starting an antidepressant and is wondering about what side effects she might expect. What are some of the common side effects of antidepressants? (Select all that apply.)

*Drowsiness

*Increased appetite

*Nausea​

*Dry mouth

*Weight gain

Besides being used as an antidepressant, bupropion is indicated by the FDA for 1._________________

1. smoking cessation

While on a monoamine oxidase inhibitor, which condition is caused by ingesting foods that are high in tyramine?

Hypertensive crisis

Which antidepressants are safe to take before eating steak and cheese? (Select all that apply.)

*amitriptyline

*venlafaxine

*wellbutrin