4) Inhibition of DNA and RNA

Fluroquinolones

stops the bacteria from untwisting and separating its DNA for replication by blocking topoisomerase.

Topoisomerase

an enzyme class that untwists and separates DNA during replication

Fluroquinolones in gram negative

Fluroquinolones target DNA gyrase

Fluroquinolones in gram positive

Fluroquinolones target topoisomerase IV

Fluroquinolones spectrum

it is a board spectrum for both gram negative and positive bacteria

Fluroquinolones 1

ciprofloxacin

Fluroquinolones 2

levofloxacin

Fluroquinolones 3

moxifloxacin

Fluroquinolones 4

ofloxacin

Rifampin

it interfere with RNA polymerase while transcription stopping mRNA production

Rifampin spectrum

active against gram positive and some gram negative like Neisseria meningitiidis

Pulmonary tuberculosis

rifampin

Biofilms on prosthetic devices

rifampin

rapid development of resistance

Rifampin