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Major sensory relay/filter
Thalamus
Homeostasis / visceral control / “thermostat”
Hypothalamus
Biological clock
Suprachiasmatic nucleus
Satiety / suppress food intake
Ventromedial hypothalamic nucleus
Pineal gland secretion
Melatonin
Speech production
Broca
Language comprehension
Wernicke
Primary motor cortex
Precentral gyrus, frontal lobe
Primary somatosensory cortex
Postcentral gyrus, parietal lobe
Coordination/posture/balance
Cerebellum
Piriform
Smell / olfaction
Fear/anger emotional cues
Amygdaloid body
Graded vs. action potentials
Graded: short, variable strength, weaken with distance, can summate. AP: long-distance, all-or-none.
AP initiation
Initial segment / trigger zone.
AP ion movements
Depolarization = Na⁺ IN. Repolarization = K⁺ OUT. After-hyperpolarization = K⁺ channels remain open longer.
Stimulus strength vs. speed
Stronger stimulus → higher firing frequency, not greater AP amplitude. Larger diameter + myelin → faster conduction.
Saltatory conduction
APs regenerate at nodes of Ranvier along myelinated axons.
Chemical synapse
AP arrives → Ca²⁺ IN → vesicle exocytosis → transmitter binds → postsynaptic graded potential.
Ending transmitter effects
Reuptake, enzymatic degradation, diffusion away.
EPSP vs. IPSP
EPSP: depolarizes toward threshold. IPSP: typically hyperpolarizes away; K⁺ OUT or Cl⁻ IN.
Temporal vs. spatial summation
Temporal = one neuron, rapid repeated inputs. Spatial = multiple neurons, different locations.
Neurotransmitters
ACh: skeletal NMJ. NE: most sympathetic postganglionic neurons. GABA: inhibitory brain. Glutamate: excitatory brain.
Receptors
Effect depends on receptor. Direct/fast = ion channel. Indirect = receptor → G protein → adenylate cyclase → cAMP.
Location terminology
Cell bodies: nucleus CNS / ganglion PNS. Axon bundles: tract CNS / nerve PNS.
Astrocytes
Regulate the chemical environment around CNS neurons.
Anterior crossing, most joints
Flexion
Posterior crossing, most joints
Extension
Lateral shoulder crossing
Abduction — away from midline
Medial shoulder crossing
Adduction — toward midline
Parallel versus pennate muscles
Parallel: greater shortening, less force
Bipennate/multipennate muscles
Many short, oblique fibers packed together: greater force, little shortening
First-class lever
Fulcrum in the middle
Standing on toes: second class
Load in the middle; force advantage
Most skeletal muscles: third class
Effort in the middle; speed/range advantage, force disadvantage
Second versus third class
Second = strength; third = speed/range