Lecture 11 a Granulocyte Kinetics

Which Neutrophil Bone Marrow Pool contains the largest number of neutrophils?

Maturation Pool

What is the lifespan of Neutrophils in the BLOOD?

7 hours

What pool of neutrophils are found ALONG VESSEL WALLS?

Marginated Pool

Which Neutrophil pool contains FREE neutrophils?

Circulating pool

What is the term for Neutrophils exiting the bloodstream and entering the tissue?

Diapedisis

What is the lifespan of Neutrophils in the TISSUE?

VARIES on if there is infection or not

What is the main function of Neutrophils?

PHAGOCYTOSIS

What are the 5 steps of phagocytosis in neutrophils?

1. Recognition & attachment

2. Ingestion (Invagination)

3. Killing with reactive oxygen species

4. Digestion of the bacteria

5. Neutrophil Extracellular Traps formation

What percentage of Neutrophils are in the circulating pool?

50%

What is the first recognizable stage of Eosinophils?

Eosinophilic myelocyte

What granules make up the Eosinophils?

Large, orange-red granules / CRYSTALLOID GRANULES

What is the size of mature Eosinophils?

12-15 um

BILOBED

How long do Eosinophils take to mature in the Bone Marrow?

3.5 days

Which is the main granulocyte associated with ALLERGIC RESPONSES and is a Hallmark of ALLERGIC DISORDERS

Eosinophils

What are the characteristics of the Basophil granules?

DARK purple granules that are WATER SOLUBLE

Which granulocyte releases HISTAMINE and CYTOKINES to promote inflammation?

Basophils

Which granulocyte produces IL-4?

Basophil

What does the production of IL-4 cause?

STIMULATE B cells to produce IgE antibodies

Remember that IgE is found on the surface of Mast cells and trigger degranulation

Which granulocyte also secretes histamine but is found in the TISSUES?

Mast Cells