Antibacterial Drugs by Mode of Action

Inhibit cell wall biosynthesis

Target: Penicillin-binding proteins

Drug Class: (B-lactams)

B-lactams

Penicillins, cephalosporins, monobactams, carbapenems

Inhibit Cell Wall Biosynthesis

Target: Peptidoglycan subunits
Drug Class: Glycopeptides

Inhibit Cell Wall Biosynthesis

Target: Peptidoglycan Subunit transport

Drug Class: Bacitracin

Inhibit Biosynthesis of Proteins

30s Ribosomal Subunit

50s Ribosomal Subunit

30s Ribosomal subunit

Drug Class: Aminoglycosides

30s Ribosomal subunit

Drug Class: Tetracyclines

50s Ribosomal subunit

Drug Class: Macrolides

50s Ribosomal subunit

Drug Class: lincosamides

50s Ribosomal subunit

Drug Class: Chloramphenicol

50s Ribosomal subunit

Drug Class: Oxazolidinones

Distrupt Membranes

Target: Lipopolyssacharide, inner and outer membrane

Disrupt Membranes

Drug Class: Polymyxin B

Disrupt Membranes

Colistin

Disrupt Membranes

Daptomycin

Inhibit Nucleic Acid Synthesis

RNA & DNA

Inhibit Nucleic Acid Synthesis (RNA)

Drug Class: Rifamycin

Inhibit Nucleic Acid Synthesis (DNA)

Fluoroquinolones

Antimetabolites

1) Folic acid synthesis enzyme

2) Mycolic acid synthesis enzyme

Antimetabolites (Folic Acid synthesis enzyme)

Drug class: Sulfonamides, trimethoprim

Antimetabolites (Mycolic Acid synthesis enzyme)

Drug class: Isonictinic acid hydrazide