CARDIO rule acids

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Last updated 11:28 PM on 9/28/26
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5 Terms

1
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C

Charge: more positively charged = more stable/acidic

2
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A

Atom: greater atom size and electronegativity = more stable/acidic

(size is more important)

3
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R

Resonance: more resonance structures = more stable/acidic

4
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D & I

Dipole/inductive effect: neighboring electronegative atoms = more stable/acidic (the closer to the acidic hydrogen, the more stable)

5
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O

Orbital: greater % of s character in conjugate base= more stable/acidic (example: sp3 = 25% vs sp = 50% s)