ICD-10-CM Neoplasm Coding & Sequencing (C00-D49)

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Vocabulary flashcards covering ICD-10-CM Chapter 2 Neoplasm coding terms, classifications, guidelines, and specific code exceptions.

Last updated 12:18 PM on 9/27/26
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17 Terms

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Neoplasm

Abnormal growth of tissue caused by rapid division of cells.

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Primary malignancy

The original cancer site where the tumor originated.

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Secondary (metastatic) neoplasm

Cancer that has spread from the primary site to another organ or tissue.

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Metastasis

The process by which cancer cells from a primary tumor spread to other parts of the body through the blood or lymph system, forming new tumors in distant tissues and organs.

<p>The process by which cancer cells from a primary tumor spread to other parts of the body through the blood or lymph system, forming new tumors in distant tissues and organs.</p>
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Carcinoma in situ

Early-stage cancer (stage zero) confined to the tissue of origin without invasion into surrounding tissues.

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Uncertain behavior

A classification for a tumor that is premalignant and currently benign, but cannot yet be determined as benign or malignant and has a tendency to become malignant.

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Unspecified behavior

A classification used when there is no information or least info provided regarding the stage or behavior of the tumor.

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Benign neoplasm

A non-cancerous growth of tissue, such as a lipoma or myoma.

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Z51 codes

ICD-10-CM encounter codes assigned as principal diagnosis for antineoplastic therapy, including radiotherapy (Z51.0), chemotherapy (Z51.11), and immunotherapy (Z51.12).

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Code D63.0

The ICD-10-CM code for anemia in neoplastic disease, sequenced second after the malignancy code when an encounter is solely for managing cancer-related anemia.

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Z85 series

ICD-10-CM codes used to report a personal history of malignant neoplasm when the primary malignancy has been excised/eradicated, no active treatment is directed to that site, and there is no evidence of existing disease.

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Code C80.0

The ICD-10-CM code for disseminated malignant neoplasm, unspecified, assigned only when a patient has advanced metastatic disease with no known primary or secondary sites specified.

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Code C80.1

The ICD-10-CM code for malignant (primary) neoplasm, unspecified, used only when no determination can be made regarding the primary site of a malignancy.

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Brachytherapy exception

A coding guideline rule where encounters for insertion or implantation of radioactive elements sequence the malignancy code first and omit code Z51.0.

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Breast Implant Associated Anaplastic Large Cell Lymphoma (BIA-ALCL)

A type of lymphoma developing around breast implants, assigned code C84.7A when active or C84.7B when in remission.

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Code Y84.2

The ICD-10-CM code reported for an adverse effect or complication caused by radiological procedure and radiotherapy.

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Code subcategory T45.1X5-

The ICD-10-CM code subcategory assigned for adverse effects of antineoplastic chemotherapy or immunotherapy.