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skin layers
epidermis
dermis
subcutaneous tissues
What influences skin color
Melanin: brown, genetically determined, pregnancy might change
hemoglobin: red, hemoglobin binds to oxygen for color, cyanosis
carotene: yellow, subcutaneous tissues, palms, and soles
bilirubin: yellow, RBC and liver
Hair
vellus hair: fine (peach fuzz)
terminal hair: coarse ex: hair on head, eyebrows
Seborrheic karatosis
warty, stuck on, benign growth
Benign nevi
“mole”
brown round symmetric macules
single hyperpigmented round symmetric macule
Hand, foot, and mouth
palmar / plantar aspect, unruptured vesicles
virus
Melanoma
ABCDEFG
A: asymmetry
B: border irregularity
C: Color variations
D: Diameter >6mm
E: Elevation and / or evolution
F: Firm to palpation
G: Growing rapidly over several weeks
Hair loss
diffuse: iron deficiency anemia, hyper or hypothyroidism, pregnancy / post partum, male or female pattern hair loss
patchy: alopecia areata, tinea capitis, hypothyroidism: lateral 1/3 of eyebrow
Onychomycosis
fungal infection of nail
thick, yellow, pulled away
What causes pruritus
dry skin
pregnancy
renal failure (uremia)
jaundice
lymphoma or leukemia
hyperglycemia (diabetes)
Skin history: dryness, moisture, oiliness
dryness: hypothyroidism
sweating (diaphoresis): hyperthyroidism, angina
oiliness: acne vulgaris
excessive bruising
thrombocytopenia
hematologic malignancies
vonWillebrand’s disease
hemophilia
vitamin K deficiency
Diabetes mellitus skin manifestation
velvety hyperpigmented plaques
mostly on neck, flexural surfaces, intertriginous surfaces
ex: axilla
systemic lupus erythathematosus (SLE) skin manifestation
malar rash
symmetric erythema on bridge of nose and cheeks
looks like a butterfly rash
small discrete erythematous macules / papules with scaling
dark skin: purple
Hypercholesterolemia skin manifestation
xanthoma
flat fatty plaques
high cholestrol
anywhere, mostly on joints, hands, feet eyelids
liver cirrhosis skin manifestation
spider angioma, caput medusa
Hyperthyroidism skin manifestation
pretibial myxedema
thickening of anterior skin with slight redness and papules
HIV / AIDS skin manifestation
Kaposi sarcoma
scattered purple plaques on skin and mucous membranes
Scabies skin manifestation
highly contangious due to person to person contact
intertriginous areas, flexor space of wrist, belt line
like to burrow in a linear distribution
hair palpation
finer hair: hyperthyroidism
coarser hair: hypothyroidism
Cyanosis
reaction to cold
raynaud’s phenomenon
heart or lung disease
jaundice
RBC hemolysis ex: sickle cell disease
liver disease
pallor
anemia
Hyperpigmentation
melasma / linea nigra: pregnancy
bronze hyperpigmentation: primary adrenal insufficiency (Addison’s disease - adrenal glands can’t produce enough hemoglobin), hemochronotosis
Hypopigmentation
vitiligo
tinea versicolor: fungal, ringworm
varicose veins
distended superficial veins
cherry angioma
benign made of small cluster of blood
ecchymosis
trauma / abuse
bleeding disorders
petechia / purpura
meningitis, bleeding disorders, vasculitis (autoimmune inflammation of blood vesicle)
ulcers
poor arterial supply, poor venous return, diabetes
edema causes
heart failure
liver disease
renal disease
myxedema (thyroid disease)
venous disease: poor venous return, thrombosis
Macule
primary lesion
flat, non palpable < 1 cm
drug eruption macule
erythematous confluent macules on arms, chest, and back
patch
primary lesion
macule > 1 cm
tinea cruris
bilateral reddish brown, geographic patches with peripheral scaling on inner thighs, sparing the scrotum
seborrheic dermatitis
bilaterally symmetric erythematous patches on central cheeks, eyebrows, and nasolabial folds with overlying greasy scale
papule
primary lesion
raised, palpable <1 cm
squamous cell carinoma
rough papule that bleeds easily and don’t completely heal, firm borders, central umbilication
basal cell carcinoma
oval pink pearly papule with overlying telangiectasias
plaque
primary lesion
papule >1 cm
nodule
primary lesion
larger deeper papule
vesicle
primary lesion
fluid filled, raised, <1 cm
bulla
primary lesion
vesicle >1 cm
pustule
primary lesion
exudate filled, raised, <1 cm
wheal
primary lesion
localized migratory edema
crust
secondary lesions
dried exudate overlying
erosion
secondary lesions
loss of epidermis that heals without scarring
Ulcer
secondary lesions
full thickness loss of epidermis with damage to the dermis
Fissure
secondary lesions
linear break in the skin
Scale
secondary lesions
increased accumulation of keratinized skin with shedding / exfoliation
Scar
secondary lesions
permanent fibrosis
molluscum contagiosum
multiple small pink firm smooth domed papules with central umbillications
psoriasis
scattered erythematous to pink well circumcised flat topped plaques on extensor surfaces, with overlying silvery scale
auspitz sign: pinpoint bleeding when scale is removed
koebner’s phenomenon: psoriatic lesions at site of trauma
atopic dermatitis (eczema)
pruritic erythematous lichenified (thickened from rubbing) poorly circumcised plaques
pityriasis rosea
herald patch is a single oval, flat topped superficial erythematous to skin colored plaque
sebacious cyst (epidermal inclusion cyst)
firm nodule with overlying black comedone or punctum with expressible foul smelling cheesy material
lipoma
painless, slow growing rubbery nodule composed of adipose tissue
herpes zoster
grouped 2-5 mm vesicles on erythematous base in a dermatomal distribution that does not cross the midline
contact dermatitis
scattered 2-5 mm erythematous papules and vesicles with transudate crust, some with linear arrays
acne vulgaris
noninflammatory open and / or closed comedones (blackheads and whiteheads) and inflammatory lesions (papules, pustules, cysts, or noduels) typically located on face, neck, back, chest and upper arms
rosacea
inflammatory facial flushing, erythema, papules, pustules, and telangiectasias
“adult acne” looks like flushing
abscess
collection of pus, often with central pustule or drainage site
furuncle: at hair follicle
carbuncle: collection that connect and drain
uritcaria
migratory edematous geographical wheals of various sizes
Impetigo
red macule or papule that progressed to a vesicle and then to a honey colored crusted lesion
herpes simplex labialis or genitalis
papules on erythematous base within 24 hours of produme, progress to vesicle within hours, vesicles rupture leaving erosion that crusts then heals
primary HSV lesions start off as gingivostomatitis typically on vermillion border of lip / hard palate
HSV genitalis typically 4-7 days after sexual exposure
arterial insufficiency
ulcer from poor arterial flow occurring on toes and sites of trauma; may occur with gangrene
Venous insufficiency
ulcer from venous stasis occurring on medial ankle without gangrene
diabetic ulcer
ulcer often precipitated by trauma on distal or dorsal toes, plantar metatarsal heads, and the heel, may occur with gangrene
tinea pedis (athletes foot)
fungal infection of the foot that commonly presents with interdigital erythema, scaling, maceration, and fissures
keloid scar
raised hypertrophied scar that extends beyond the original wound barriers
acne vulgaris
pitting and scarring secondary to severe nodulocystic acne
Calor
increased temperature
infection or inflammation
poikilothermia
decreased arterial flow, decreased temperature
clubbing
convex angle of the nail plate associated with hypoxemia
spoon nails
concave angle of the nail plate associated with iron deficiency anemia
beau’s lines
transverse depressions on nails associated with severe disease
paronychia
abscess and / or cellulitis adjacent to nail
splinter hemorrhages
red / brown linear streaks in the nails bed associated with acute infectious endocarditis
tinea versicolor
multiple 2-5 mm hypopigmented, hyperpigmented, or tan round to oval macules on upper neck and back, upper chest, and arms with slight inducible scale on scrapping
skin tags
multiple 2 - 4 mm soft fleshy skin colored to light brown papules on lateral neck and axillae folds
guttate psoriasis
scattered erythematous round drop like flat topped well circumscribed scaling papules and plaques on trunk
plaque psoriasis
scattered erythematous to bright pink well circumscribed flat topped plaques on extensor knees and elbows with salivary scale
nummular dermatitis
multiple round coin like eczematous plaques on arms and legs and abdomen with overlying dried transudate crust