Biological explanations description

Limbic system

Amygdala Hippocampus Hypothalamus

Davis et al

too little dopamine in D1 receptors of the frontal lobe of those with- ve symptoms snd cognitive impairments.

Griffith et al

induced psychosis in volunteers with dextro- amphetamine. volunteers showed abrupt paranoid delusions and cold detached responses

why was hypothesis too simple

administering drugs reducing dopamine had little/ no effect on negative symptoms

Seeman and Lee

researched showed the impact of antipsychotic drugs on D2 receptor.

2 main pathways associated with schizophrenia

Mesocortical/ mesolimbic

where does the mesocortical pathway take signals from and to

ventral tegmental area to the frontal lobe

what does the mesocortical pathway regulate

emotional responses, motivation, cognition

Davis et al

too little dopamine in D1 receptors of the frontal lobe of those with -ve symptoms snd cognitive impairments

drug used by Griffith to induce psychoses

dextroamphetamine

where were D2 receptors found to make it the main focus

subcortical regions of the limbic system

what does the limbic system regulate

emotion, memory formation, arousal

why was the initial hypothesis too simple

the dopamine reducing drug did not help negative system