Hemoglobin Function 4

Haemaglobin

is metalloprotein found in RBC

Metalloprotein

metal ion in protein

96%

dr weight of RBC contains iron

Adult male hemaglobin range

14.0 - 17.4 / 13.8 - 17.0 g/dl

Adult female (non pregnant) hemaglobin range

12.0-16.0 / 12.0 - 15.0 g/dl

Haemoglobin function

it carries O2 and CO2, maintains it shape and red color, binds other ligands, act as buffer and produce active substnce when it break down

Transportation of oxygen

its from lungs to all tissues of the body

Oxygen binding capacity of haemoglobin

1 gram of haemaglobin binds to 1.34 ml of O2

binding oxygen oxidizes

fe2 into fe 3

oxyhemaglobin

oxygen bound to hemaglobin / artery

deoxyhemaglobin

oxygen unbound to hemaglobin / veins

2 state

T state and R state

R State

Happens in lungs, relaxed, and where haemaglobin had high oxygen affinity, it attracts more haemaglobin per haemaglobin pocket

it have more O2 and less waster, we have High ph, Low CO2, Low 23 BGP

2 3 BPG

Biphosphoglyceric acid - controls opening and closing of pocket

T State

Happens in tissue, tense, where haemaglobin has low oxygen affinity, and oxygen release

if haemaglobin have high affinity the oxygen it will never release in tissue

Every ____ of oxygenated blood carries ____ of CO2 to tissue

100ml and 5ml

Carbaminoglobin

only 20-25% of CO2 transported bound to haemaglobin

Bicarbonate

rest of 70-85% converted travels

Carbonic anhydrase

process sped up enzyme

250 times

haemaglobin has more then high affinity for carbon monoxide

Carbon monoxide

toxic compound, we can inhale it by population or heavy smokers

Result of carbon monoxide

If haemaglobinn kept taking carbon monoxide instead of oxygen, we will have low oxygen when can cause hypoxia and when it happend it can cause headache, nausea and you inhdale itm it can cause heaache nausem in baca ne 20% block active binding side of oxygen in heavy smokers