Steps of EGF-stimulated MAPK signal transduction (BMED 5207 exam 4)

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9 Terms

1
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step 1 of EGF-stimulated MAPK signal transduction

EGFR dimerizes

2
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step 2 of EGF-stimulated MAPK signal transduction

EGFR is auto-phosphorylated at tyrosine residues

3
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steps 3 of EGF-stimulated MAPK signal transduction

Grb2 binds to phosphorylated tyrosine via its SH2 domain

4
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step 4 of EGF-stimulated MAPK signal transduction

Grb2 binds to SOS via its SH3 domain

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step 5 of EGF-stimulated MAPK signal transduction

SOS is activated

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step 6 of EGF-stimulated MAPK signal transduction

GTP exchange for GDP on Ras

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step 7 of EGF-stimulated MAPK signal transduction

activated Ras binding to Raf, activating it

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step 8 of EGF-stimulated MAPK signal transduction

MEK is activated

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step 9 of EGF-stimulated MAPK signal transduction

MAPK is activated