Pceut Equasions

2) Therapeutic index

TI= TC50/EC50

2) First order kinetics

dc/dt= -K x C

2) Bioavailability (F)

F (%)= AUCoral/AUCiv x 100

2) Total drug in body

Vd x the plasma drug at conc 0

3) Signed error

Signed error = observed - refrance

3) Absolute % error

|observed - refrance|/ refrance x 100

3) Mass

density x volume

3) Model % error

SR/ mass weighed x 10

3) Minimum weighable quantity

MWQ= SR/allowed fractional error

3) Minimum volume

deviation/allowed fractional error

3) Drug in aliquot

Initial drug x aliquot mass/total mixture mass

4) Dilution

(C1)(V1)=(C2)(V2)

4) Molarity (M)

mol of solute/L of solution

4) Molality (m)

mol of solute/kg of solvent

5) meq of ion

mmol of ion x mmol of ion x |z|

z= charge

5) Equivalent weight

MW/n ( n is charge factor )

5) Equiavalents

Eq= mass (g)/equivalent weight

5) Charge factor (N)

n= Eq/L of solution = M x n

6) P

Conc in octanol/Conc in water

6) Cosolvalency-

7) Osmolarity

Osmoles of particles/L of solution

7) Osmolality

Osmoles of particles/kg of solvent

8) mg%

mg/dL (deciliter

Freezing point, V method, e method