Types of Hypersensitivity Reactions

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Last updated 2:35 AM on 10/13/26
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8 Terms

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Type I

Immediate / IgE ➔ Mast cell degranulation ➔ Anaphylaxis, Asthma

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Type II

Cytotoxic / IgG, IgM ➔ Surface antigen binding ➔ Cell lysis / Transfusion reaction

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Type III

Immune Complex / IgG, IgM ➔ Tissue deposition ➔ SLE, RA pannus, Vasculitis

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Type IV

Delayed / T-Cell ➔ 24-72 hour response ➔ Contact Dermatitis, PPD test

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Type 3 (Immunocomplex Reaction)

Excess antigens cause immune complexes to form in the blood, lodge in small blood vessels, and trigger inflammation.

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Type 3 (Immunocomplex Reaction) Examples

RA, SLE

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Type 4 (Delayed Hypersensitivity Reaction)

• Occurs 12-72 hours following

exposure

• Characterized by edema,

induration, ischemia, and tissue

damage to occur at site of

exposure

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Type 4 (Delayed Hypersensitivity Reaction) Examples

Contact Dermatitis