NTEGUMENTARY – All levels should understand:
i. Functions of the integumentary system (e.g., physical protection, Vitamin D synthesis, sensation,
excretion, temperature regulation, role of the skin in innate immunity)
ii. Anatomy and histological characteristics of the layers of the skin
iii. Anatomy and histological characteristics of the component parts of the skin: hair (e.g., types,
appearance, growth cycle), nails, integumentary glands (e.g., eccrine vs apocrine), and sensory
receptors
iv. Skin color, skin texture, and the effects of aging on the skin
v. Dermatological features (e.g., freckles, moles, scales, calluses, birthmarks, fingerprints)
vi. The diseases on each level from the cell to the whole person as listed: wounds affecting the skin
(limited to burns and their classification, sunburn), allergens (e.g., poison ivy, metals), human
papillomavirus (HPV), infections (limited to boils, carbuncles, athlete’s foot, impetigo, erysipelas,
cellulitis, Hansen’s Disease, chickenpox, shingles), common inflammatory disorders (limited to
psoriasis, dermatitis), and skin cancer (limited to melanoma, basal cell carcinoma, squamous cell
carcinoma, Kaposi’s sarcoma, Merkel cell carcinoma)
vii. Treatments and/or prevention for all conditions listed above (drugs, surgery, etc.)
State and National Level Only:
viii. Cellular components of cutaneous immune system (e.g., dermal dendritic cells, dermal macrophages)
ix. Additional disorders: immunologic and inflammatory disorders (limited to rosacea, vitiligo, bullous
pemphigoid, Stevens-Johnson syndrome, erythema nodosum, erythema multiforme, alopecia)
National Level Only:
x. Additional disorders: Congenital disorders (limited to albinism, xeroderma pigmentosum),
systemic disorders and their effect on skin (limited to acanthosis nigricans), benign lesions
(limited to actinic keratosis)
xi. Treatments and/or prevention for all conditions listed above (drugs, surgery, etc.)
xii. Aspects of wound healing including, but not limited to: inflammation, necrosis, apoptosis,
vasodilation, and clotting
b. SKELETAL SYSTEM – All levels should know and understand:
i. Bones of the axial and appendicular skeleton; label the basic surface anatomy of a bone as shown on
a diagram and/or normal X-ray, CT and MRI
ii. Name, structure and function of joint types and muscle, tendon and ligament attachments that
surround the joints and the ranges of motion allowed by each type (e.g., ball and socket)
iii. Structure and microscopic function of bones, bone marrow and cartilage (e.g., storage, osteon,
blood cell production)
iv. Tension production (e.g., sarcomere length-tension relationship, muscle twitches, motor units)
v. Skeletal system role in calcium and phosphate balance
vi. Effect of hormones (e.g., PTH, vitamin D, estrogen) on the skeletal system
vii. Cellular composition of bones (e.g., RANKL role in bone cell maturation), bone marrow and
cartilage
viii. Development and maturation of bones at the cellular and gross anatomical levels
ix. Types of vertebrae (e.g., cervical, thoracic and lumbar)
x. Characteristics and radiological features of bone diseases/disorders from the cell level to the whole
person as listed: osteoarthritis and rheumatoid arthritis (know how to distinguish both from
one another), gout, osteoporosis, osteomalacia/rickets, scoliosis, kyphosis, lordosis, Tennis
elbow, Golfer’s elbow, cruciate ligament tears of the knee, meniscus tears of the knee, and
septic arthritis
xi. The effects of exercise and aging on the skeletal system and the diseases mentioned
xii. Cardiac and smooth muscle roles in the body (e.g., blood circulation, digestive motility)
xiii. Fractures, including the Salter-Harris fracture classification system, causes, and treatments
State and National Level Only:
xiv. Additional diseases/disorders: spinal fractures (including specific classes), ankylosing spondylitis,
achondroplasia, osteosarcoma, and Ewing sarcoma
National Level Only:
xv. Additional diseases/disorders to know: clinical effects of spinal stenosis, foraminal stenosis,
and disc herniation on the nervous system, Osgood-Schlatter disease, plantar fasciitis, Paget
disease of bone (osteitis deformans), osteoblastoma, giant cell tumor
xvi. Treatments and/or prevention for all conditions listed above (drugs, surgery, etc.)
xvii. Label the bones and sutures of the skull. Know the foramina of the skull and what neurovascular
structures pass through each.
c. MUSCULAR SYSTEM - All levels should know:
i. Functions of the muscular system (e.g., movement, blood circulation, heat production)
ii. The interaction of the skeletal and muscular systems to allow movement and maintain posture
iii. The cellular and gross anatomy of skeletal muscle, cardiac muscle and smooth muscle
iv. Tension Production (e.g., sarcomere length-tension relationship, muscle twitches, motor units)
v. Physiology of the skeletal muscle contraction and relaxation (e.g., neuromuscular junction,
excitation-contraction coupling, cross-bridge cycling)
vi. Concepts of skeletal muscle actions (e.g., agonist, antagonist, synergist muscles) of different
muscles on the 2025 National Major Skeletal Muscles List
vii. Location and identification (e.g., origin, insertion, function) of the muscles on the 2025 National
Major Skeletal Muscles List
viii. Exercise and aging effects on the cellular and gross anatomical structure of the muscular system
ix. Muscle and tendon injuries and their prevention (limited to strains and sprains)
x. The diseases on each level from the cell to the whole person as listed: neuromuscular junction
disorders (limited to myasthenia gravis, Lambert-Eaton myasthenic syndrome), immunologic
and inflammatory disorders (limited to polymyalgia rheumatica, polymyositis, and
dermatomyositis), infectious disorders (limited to botulism, tetanus, poliomyelitis), and pain
syndromes (limited to fibromyalgia, chronic fatigue syndrome, Carpal Tunnel Syndrome)
State and National Level Only:
xi. Energy metabolism in skeletal muscles (limited to phosphocreatine system, glycogen storage
and consumption)
xii. Additional diseases: rhabdomyolysis, Duchenne muscular dystrophy, myotonic dystrophy
xiii. Cardiac and smooth muscle roles in the body (e.g., blood circulation, digestive motility)
National Level Only:
xiv. Nerve innervation for all muscles on the 2025 National Major Skeletal Muscles List
xv. Muscle reflexes (limited to Golgi tendon organ, muscle spindle fibers)
xvi. Additional diseases: congenital disorders and iatrogenic disorders (limited to drug-induced
myositis, malignant hyperthermia)
xvii. Treatments and/or prevention for all conditions listed above (drugs, surgery, etc.)
xviii.Effects of steroid medications on muscle health
Frontalis
Orbicularis oris
Orbicularis oculi
Occipitofrontalis
Zygomaticus major
Masseter
Sternocleidomastoid
Trapezius
Buccinator
Move the Upper Extremities
Pectoralis major
Latissimus dorsi
Deltoid
Teres major
Biceps brachii
Triceps brachii
Brachialis
Brachioradialis
Palmaris longus
Flexor carpi radialis
Flexor digitorum superficialis
Extensor carpi radialis
Extensor digitorum
Extensor digiti minimi
Extensor carpi ulnaris
Infraspinatus
Supraspinatus
Subscapularis
Teres Minor
Muscles of the Trunk
External intercostals
Internal intercostals
Transverse abdominis
Rectus abdominis
Serratus anterior
Diaphragm
Move the Lower Extremities
Iliopsoas
Sartorius
Gluteus maximus
Gluteus medius
Tensor fasciae latae
Adductor longus
Gracilis
Semimembranosus
Semitendinosus
Biceps femoris
Rectus femoris
Vastus lateralis
Vastus intermedius
Vastus medialis
Tibialis anterior
Gastrocnemius
Soleus
Peroneus longus
Peroneus brevis