Normal Blood Pressure (BP): < 130/80
Mechanisms Influencing BP:
Cardiac Output control
Control systems
Arterial Baroreceptor System
Regulation of body fluid
Renin-angiotensin-aldosterone system
Vascular autoregulation
Essential Hypertension: No identifiable cause
Secondary Hypertension: Due to identifiable cause (e.g., kidney disease)
Hypertensive Crisis: Malignant hypertension, rapidly progresses >200/130
Family history
African-American ethnicity
Hyperlipidemia
Smoking
Age: 60 years old or post-menopause
Obesity/overweight
Sedentary lifestyle
Stress
Kidney disease
Primary aldosteronism
Cushing’s disease
Brain tumors
Encephalitis
Pregnancy
Certain medications (e.g., estrogen, glucocorticoids)
Affects ~90 million worldwide
Can shorten life expectancy
High American obesity rates impact hypertension
History: Focus on risk factors and subjective data (e.g., dizziness, headache, fainting)
Physical Assessment:
Measure blood pressure
Cardiovascular assessment
Inquire about eye exams
Factors: Occupation, stress, economics
Essential Hypertension: No specific lab test
Secondary Hypertension: Dependent on underlying conditions
Lifestyle Changes (Foundational)
Smoking cessation
Avoid caffeine and sodium
Weight reduction
Moderate alcohol intake
Regular exercise
Stress management
Diuretics
Lipid lowering agents
Antihypertensives (Beta blockers, ACE inhibitors, ARBs)
Thiazide Diuretics:
Most commonly used for hypertension
Act on sodium and water balance in the distal convoluted tubule
Examples: Hydrochlorothiazide (HCTZ)
Uses: Edema, hypertension
Side Effects: Hypokalemia, hyperglycemia, increased uric acid levels
Contraindications: Gout, diabetes
Patient Education: Take in the morning; monitor BP/HR
Mechanism: Act directly on loop of Henle, inhibiting sodium and chloride reabsorption
Examples: Furosemide (Lasix), Bumetanide (Bumex)
Uses: Heart failure, edema, pulmonary edema
Side Effects: Hypokalemia, orthostatic hypotension, hyperglycemia, dizziness
Patient Teaching: Monitor vital signs, rise slowly, need for potassium supplements
Action: Inhibit sodium reabsorption in exchange for potassium
Example: Spironolactone (Aldactone)
Side Effects: Weakness, hypotension, irregular heart rate
Patient Teaching: Monitor BP/HR, decrease potassium intake
Function: Counteracts arrhythmias by blocking calcium access, reduces contractility
Examples: Amlodipine (Norvasc), Diltiazem (Cardizem)
Side Effects: Bradycardia, hypotension
Patient Teaching: Monitor HR/BP
Mechanism: Blocks conversion of Angiotensin I to II, causing vasodilation
Examples: Lisinopril, Benazepril
Side Effects: Hypotension, nagging cough
Patient Teaching: Monitor BP/HR
Action: Blocks binding of Angiotensin II, leading to vasodilation
Examples: Candesartan, Losartan, Valsartan
Side Effects: Hypotension
Mechanism: Inhibits adrenergic receptors, decreasing heart rate
Examples: Atenolol, Carvedilol
Side Effects: Hypotension, bradycardia, fatigue, sexual dysfunction
Patient Teaching: Monitor HR/BP, caution for orthostatic hypotension
Importance of medication compliance, often lifelong
Educate on potential side effects and consequences of noncompliance
Encourage home monitoring of BP/HR, lifestyle adjustments
Definitions:
Arteriosclerosis: Thickening/hardening of arterial walls
Atherosclerosis: Formation of plaque within artery walls
Fatty streak formation due to inflammation, calcification, hemorrhage
Can lead to partial or complete blood flow occlusion
Genetics, age, hypertension, abnormal lipid levels, diabetes, smoking, obesity, sedentary lifestyle
Evaluate blood pressure, carotid pulses, and capillary refill
Perform lipid panel tests for LDL, HDL, cholesterol levels
Slow progression through lifestyle changes—smoking cessation, exercise, healthy nutrition
Medications:
Statins to lower LDL (e.g., Mevacor, Zocor)
Side effects: muscle tenderness, possible liver enzyme issues
Fibrates (e.g., Lopid, Tricor) to take with meals, avoid fatty foods
Defines altered blood flow; also known as Lower Extremity Arterial Disease (LEAD)
Risk: Increased likelihood of angina, myocardial infarction, stroke; more prevalent in older adults, especially African-Americans and women post-menopause
Stages:
Asymptomatic; may have absent pulses
Intermittent claudication (muscle pain, cramping relieved by rest)
Rest pain (pain in toes/feet)
Ulcers and gangrenous tissue
Include exercise tolerance testing and imaging (e.g., arteriography)
Routine exercise, manage positioning, and promote vasodilation
Avoid tight clothing, caffeine, nicotine, and stress
Medications include angioplasty, stent placements, or surgical revascularization as needed
Chronic condition requires ongoing care
Education to promote vasodilation and minimize risk factors
Common Cause: Embolus, sometimes thrombus
Assessment: Sudden severe pain, cold, and pulselessness in extremity
6 P’s of Ischemia:
Pain
Pallor
Pulselessness
Paresthesia
Paralysis
Poikilothermia
Thrombolytics, noting possible bleeding complications
Dilation (ballooning) of an artery; most commonly caused by atherosclerosis
Dissecting aneurysm, thoracic aneurysm, abdominal aortic aneurysm (AAA)
Often discovered incidentally; possible pulsations or pain present
Smoking as primary cause; assessment includes claudication and neuropathy
Interventions: Total tobacco abstinence, medication to promote vasodilation
Condition involving vasospasms; managed through patient education (avoid cold and stress)
DVT: Thrombus that poses risk for pulmonary embolism
Prevention: Avoid certain contraceptives, stay hydrated, mobilize during prolonged inactivity
Calf/groin pain, unilateral leg swelling, localized edema; diagnostic assessments include venography and duplex ultrasonography
Rest with limb elevation, drug therapies including heparin or warfarin; monitor INR
Possible surgical management (thrombectomy, IVC filter)
Result from prolonged venous hypertension; symptoms include edema and stasis ulcers
Management:
Use elastic compression stockings, elevate legs regularly, and follow proper skin care protocols
Surgical Options: Debridement only for severe ulcers
Community-Based Care: Positioning, weight management, and mild exercise encouraged
Characterized by protruding, darkened veins; management includes compression and potential surgical options.