Front: What are the two main types of brain cells?
Back: Glia and Neurons
Front: What is the function of glial cells?
Back: Support cells that play structural and metabolic roles in maintaining the brain. They:
Maintain the biophysical environment for nerve function
Provide armature
Manage blood compounds' access to neurons
Serve as natural insulation
Front: What is the function of neurons?
Back: Neurons perform computations and form the foundation of mental function.
Front: What is the cell body of a neuron?
Back: The large center of the cell that contains all machinery needed to keep the cell alive, processes sugars and oxygen, and contains DNA.
Front: What are dendrites?
Back: Inputs to a nerve cell that allow for the mathematical integration and analysis of signals from other cells.
Front: What is the function of an axon?
Back:
Acts as the output wire for the neuron
Broadcasts outputs of dendritic computations to other neurons
The tips of axons make physical contact with dendrites of other neurons
Front: What is the nerve terminal (axon terminal)?
Back: The contact point between neurons, specialized to maximize computational flexibility.
Front: What is a synapse?
Back: The junction between an axon terminal and a dendrite that allows a receiving neuron to perform calculations on received signals.
Front: What are ions?
Back: Atoms or molecules that have a net electric charge.
Front: What is electric charge?
Back: A basic property of matter carried by some elementary particles that governs how particles are affected by an electric or magnetic field.
Front: What is the neuronal membrane?
Back: The neuronal membrane restricts the flow of chemicals in and out of the cell and contains channels that allow permeability to water-based chemicals.
Front: What is diffusion in the movement of ions?
Back:
Ions dissolved in water are in constant movement
Ions distribute evenly in a solution from high to low concentration regions
Front: How does electricity relate to the movement of ions?
Back:
Opposite charges attract, like charges repel
Electric potential (voltage): Force exerted on a charged particle, reflecting the difference in charge between negatively and positively charged terminals
Membrane potential: Voltage across the neuronal membrane at any moment
Front: What is resting membrane potential?
Back:
Restriction of flow through the membrane creates a stable equilibrium
Diffusion: High concentration of sodium outside the neuron pulls sodium inside
Electricity: Positive charge of the cell pushes excessive sodium outside
Resting potential: The equilibrium point
Opening the channels increases diffusive force, shifting to a higher voltage inside the cell
Front: What are neurotransmitters?
Back: Chemicals that temporarily open ion channels on dendrites, briefly changing the electrical voltage across each neuron's membrane.
Front: What is an action potential?
Back:
Ion channels in axons are voltage-gated
Channels open when the voltage near them exceeds a fixed threshold, further increasing voltage
A wave of action potential propagates down the axon to the terminal
Frequency of openings can communicate continuous voltage levels rather than binary signals
Front: What is the firing rate of a neuron?
Back: The rate at which action potentials are generated, which is roughly a linear function of dendritic voltage.
Front: How does the brain encode negative signals and limited precision?
Back:
The brain encodes separate positive and negative segments
The range of firing rate is limited to 50Hz-zero, which restricts precision
This limitation can be overcome by involving more than one neuron
Front: What is the metabolic cost of information transmission?
Back:
Generation of action potentials, neurotransmitter release, and dendritic equilibrium maintenance are metabolically costly
20% of oxygen and sugar in an adult brain, and 50% in children, is consumed for these processes
Front: What is information transmission without spikes?
Back:
Light enters the eye, stimulating the retina and exciting a neuron
The first two layers of neurons are in constant communication, meaning no spike is needed
Front: Why does the brain use spikes?
Back:
Accuracy: Reacts to changes in less than a millisecond
Speed: Ensures rapid communication
Distance: Signals can travel along meters of axon
Front: What are the main subdivisions of the brain?
Back:
Telencephalon (~ cerebrum): Includes the cerebral cortex and basal ganglia
Metencephalon (~ cerebellum)
Brain stem
Front: What is the function of the basal ganglia?
Back:
Striatum encodes values of options
Receives inputs from the frontal cortex and sends outputs to other basal ganglia regions
Particular interest: dopamine neurons, which encode reward-prediction error signals
Front: What is the cerebral cortex?
Back:
A large, 6-layered sheet, with each layer serving a function
Grey matter: Cell bodies
White matter: Runs of axons serving connectivity
Brodmann areas indicate functional subdivisions
Front: What is the amygdala responsible for?
Back:
Part of the telencephalon
Super old structure responsible for fear
Receives sensory inputs and sends output to the hypothalamus for somatic responses
Front: What are the main types of neuroscience research methods?
Back:
Measurement techniques: Correlational, observe brain function changes
Manipulation techniques: Causal, examine how perturbations change behavior
Front: What factors determine the choice of research method?
Back:
Temporal resolution: Frequency of measurements
Spatial resolution: Ability to distinguish adjacent regions
Invasiveness
Front: What is the absolute threshold?
Back: The minimum intensity of a stimulus that can be reliably detected.
Front: What is the difference threshold?
Back: The smallest difference between two stimuli that can be reliably detected.
Front: What is Weber's law?
Back:
The Just Noticeable Difference (JND) follows a constant ratio between the change and the base.
This ratio can describe the difference threshold.
Weber fraction formula: ΔR = cR or ΔR/R = c
A modified version includes sensory noise (a): ΔR = c(R + a), where a is the amount of sensory noise that exists when R = 0.
Front: What are the assumptions of Fechner's law?
Back:
Weber's law is correct.
JNDs are equal psychological increments in sensation magnitude regardless of ΔR size.
Formula: S = k log R
S = Magnitude of psychological sensation
R = Intensity of physical stimulus
Front: What is Steven's law?
Back:
Describes sensation magnitude estimation based on stimulus intensity changes.
Records S by asking subjects to rate perception (e.g., from 1 to 10).
Formula: S = aR^b
b values differ for different stimuli:
Brightness: 0.3
Lengths: 1
Electric shock: 3.5
Front: What is the perception of numerosity?
Back:
Counting up to 3 is easy, but beyond that, it becomes difficult.
Subitization: Fast counting without actually counting.
Front: What factors influence numerosity perception?
Back:
Overestimation: We tend to overestimate numerosity if objects are regularly spread out on a page.
Distance effects: Two distant numerosities are easier to distinguish.
Magnitude effects: For equal distance, we struggle more to distinguish between larger numerosities.
Formula: (N₁ - N₂) / (N₁ + N₂)
Front: What is the mental compression of large numbers?
Back:
We tend to compress large numbers into a log-like scale rather than a linear one.
Front: How do we perceive the number line?
Back:
We associate larger numbers with the right side.
This perception does not depend on literacy.
Early in life, numbers are perceived in a logarithmic manner, but after around 4th grade, this perception transitions to a linear scale.
Front: What is Bayes' rule?
Back:
Formula: P(A | B) = (P(B | A) * P(A)) / P(B)
Extended version: P(A | B) = (P(B | A) * P(A)) / [(P(B | A) * P(A)) + (P(B | ¬A) * P(¬A))]
Front: What is Bayesian updating?
Back:
The process of updating beliefs about a state of the world in accordance with Bayes’ Rule.
Front: How does Bayesian updating work for a continuous state of the world?
Back:
The world state is modeled as θ ~ N(m, σ²), where m is the mean and σ² is the variance.
Precision ρ is defined as 1 / σ².
A learner updates their belief after observing a noisy signal s about θ.
Formula for updated belief: m' = βs + (1 - β)m, where β = ρₑ / (ρ + ρₑ).
Front: What is the Bayesian brain hypothesis?
Back:
The hypothesis states that the brain receives noisy signals about reality and decodes them optimally by integrating prior knowledge.
Estimation biases should change across contexts.
Front: What is the central tendency of judgment?
Back:
Judgments gravitate towards the mean magnitude: lower values are overestimated, and higher values are underestimated.
Explanation: noisy encoding + optimal decoding.
The brain’s best guess of a stimulus magnitude is E[θ̂] = (1 - β)m + βθ.
Model predicts underestimation for large θ and overestimation for small θ.
Threshold: θ = m.
Front: What is the fallacy about independence?
Back:
Assuming two things are independent when they are not.
Example: Investing in stocks and bonds for diversification – perceived as independent but actually dependent.
Example: The probability of getting heads after five tails – perceived as dependent but actually independent.
Front: What is the gambler's fallacy?
Back:
The mistaken belief that a system has memory when it does not.
Example: Believing a slot machine is "due" for a win.
Front: What is the hot hand fallacy?
Back:
The belief that if someone is successful in a task now, they will continue to be successful in the future.
Example: "I scored three basketball shots, I'll score the fourth."
Front: What is the representativeness heuristic?
Back:
The probability of an outcome is judged by how representative it is of the process.
Example: People incorrectly estimate the probability of coin sequences like HHHHHH < HHHHHP < HPPHHP.
Leads to predictable biases and mistakes.
Front: What is the law of small numbers?
Back:
The tendency to overestimate how well small samples represent a larger population.
Example: "A sample of 4 is enough to prove the coin is biased."
Front: What is the conjunction fallacy?
Back:
Overestimating the probability of a conjunction of events.
Example: The Linda problem (banker vs. banker-activist).
Example: Boeing has 6 million parts, each failing with a probability of 0.00001%. The probability that none fail is 0.25%, but people estimate it higher.
Front: What is the planning fallacy?
Back:
Over-optimism in estimating the time required to complete a task.
Example: PhDs take longer than planned due to optimistic assumptions.
Front: What is the disjunction fallacy?
Back:
Underestimating the probability of at least one event occurring.
Example: The probability of rolling at least one six with two dice.
Related to the birthday problem.
Front: What is base-rate neglect?
Back:
Ignoring the base rate of an event when considering conditional probabilities.
Example: Cancer screening probabilities.
Front: What is confirmation bias?
Back:
Tendency to interpret information in a way that supports existing beliefs.
Front: What is the availability heuristic?
Back:
Assessing the probability of an event based on how easily examples come to mind.
Explains:
Repeated dangerous behavior.
Why storytelling is effective.
Front: What is Sen’s α condition or Chernoff’s condition?
Back:
If a decision-maker appears to prefer x to y in one menu, this preference should not be reversed in another menu.
The choice is rationalizable if and only if it satisfies this property.
Front: What is the opportunity cost fallacy?
Back:
Explicit cost: what you pay.
Opportunity cost: the value to be forgone.
People often disregard opportunity cost in decision-making.
Front: What is the sunk cost fallacy?
Back:
The tendency to continue investing in something because of prior investment, even when it is not beneficial.
Front: What is the endowment effect?
Back:
People tend to value what they already own more than what they don’t.
A special case of status quo bias.
Front: What is loss aversion?
Back:
Losses hurt more than equivalent gains feel good.
Value function: Suppose the initial endowment is (m, w): V(m - m, w - w) = v(m - m*) + v(w - w*)**
Loss aversion factor λ > 1, typically around 2.
Front: What is anchoring?
Back:
In the absence of solid data, people use arbitrary reference points as anchors.
Anchoring heuristic: If someone with no opinion hears an action suggested, they are likely to adopt it.
Front: What is the compromise effect?
Back:
People tend to choose an option that is a compromise between two extremes.
Front: What is the decoy and asymmetric dominance effect?
Back:
A tendency to choose an option that is strictly better than another, making it more attractive.
Front: What is the independence of irrelevant alternatives?
Back:
If C is chosen from a set, it should still be chosen if a new option is introduced that does not affect its relative ranking.
Introduction of a new point should not affect judgment.
Front: What is normalization in decision-making?
Back:
The brain re-expresses input values relative to other inputs.
Formula: a / (a + b).
Front: What is pairwise normalization in decision-making?
Back:
Given a choice set X, an option x with {x₁, ..., xₙ} unnormalized values is evaluated as: V(x; X) = ∑(xₙ / (xₙ + yₙ))
A decision-maker prefers x over y if V(x; X) > V(y; X).
Front: How does the brain apply normalization in decision-making?
Back:
The brain compares input values relative to alternatives.
Helps explain context-dependent choices.