Lecture 2 (Part 2) Notes

Chapter Five: Histology

  • Histology is the study of tissues.

  • Tissues consist of collections of cells that serve a similar purpose or function.

  • Tissues can be made up of the same cell type or multiple cell types working together.

  • Multiple tissues form organs in the body.

Cell Estimates

  • Various estimates suggest the human body consists of approximately 50 trillion to 75 trillion cells.

  • There are roughly 200 different cell types in the human body.

    • Example: Bone has four different types of bone cells.

    • Blood has red blood cells and five different types of white blood cells, with additional developmental stages contributing to their formation.

    • Bone marrow produces cells that generate platelets.

Genetic Information in Cells

  • All somatic (non-reproductive) cells in the body share the same genome composed of genes and their variations (alleles).

  • Exception includes gametes (sperm and egg), which are haploid and contain only half the number of chromosomes.

Differentiation of Cell Types

  • Despite sharing the same genome, cells can exhibit different appearances and functions.

  • This differentiation is largely due to gene expression, which determines which genes are turned on or off in different cell types.

  • Various stimuli, including signaling pathways, influence gene expression patterns.

Importance of Histology

  • Understanding tissues helps in identifying unknown organs or diagnosing diseases based on tissue appearance.

  • Recognizing features of healthy versus diseased tissues aids in diagnosing ailments.

Focus of Upcoming Lectures

  • Next lectures will explore specific primary tissue types with a focus on epithelial tissues.

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