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Imperialism Rise in Nationalism • During the French and Industrial Revolution, nationalism continued to inspire nations to increase their political and economic power. • Nationalism became the ideal force in the political, economic, and cultural life in the world, becoming the first universal ideology-organizing all people into a nation state. Nationalism Defined • The strong belief that the interest of a particular nation-state is of primary importance. o Nation-State – a state where the vast majority shares the same culture and is conscious of it. It is an ideal in which cultural boundaries match up with political ones. • As an ideology, it is based on the idea that the individual’s loyalty and devotion to the nation-state surpass other individual/group interests. • Exalting one nation’s belief above all others and placing primary emphasis on promotion of its culture and interests, excluding the interests of others. Changing the World through a Nationalistic Vision • The French Revolution significantly changed the political world and how countries govern. • The Industrial Revolution significantly changed the economic world. • The Age of Imperialism (1870-1914) dramatically changed the political, economic, and social world. What is Imperialism? • Imperialism- The policy of extending the rule of authority of an empire or nation over foreign countries, or of acquiring and holding colonies and dependencies. Power and influence are done through diplomacy or military force. Reasons for Imperialism • There are 5 main motives for empires to seek to expand their rule over other countries or territories: 1. Exploratory • Imperial nations wanted to explore territory unknown to them. • The main purpose for this exploration of new lands was for resource acquisition, medical or scientific research. o Charles Darwin • Other reasons: o Cartography (map making) o Adventure 2. Ethnocentric • Europeans acted on the concept of ethnocentrism o Ethnocentrism- the belief that one race or nation is superior to others. • Ethnocentrism developed out of Charles Darwin’s “survival of the fittest” theory. Philosophers used the theory to explain why there were superior races and inferior races. o This became known as Social Darwinism. • Most imperial nations believed that their cultural values or beliefs were superior to other nations or groups. • Believed imperial conquest would bring successful culture to inferior people. 3. Religious • Imperial expansion promoted a religious movement of people setting out to convert new members of conquered territories. • With the belief that Christianity was superior, missionaries believed it was their duty to spread Christianity to the world. • Christian missionaries established churches, and in doing so, they spread Western culture values as well. • Typically, missionaries spread the imperial nation's language through education and religious interactions. 4. Political • Patriotism and Nationalism helped spur our imperial growth, thus creating competition against other supremacies. • It was a matter of national pride, respect, and security. • Furthermore, European rivalry spurred nations for imperial conquest. Since land equaled power, the more land a country could acquire the more prestige they could wield across the globe. • Empires wanted strategic territory to ensure access for their navies and armies around the world. • The empire believed they must expand, thus they needed to be defended. 5. Economic • With the Industrial Revolution taking place during the same time, governments and private companies contributed to find ways to maximize profits. • Imperialized countries provided European factories and markets with natural resources (old and new) to manufacture products. • Trading posts were strategically placed around imperialized countries to maximize and increase profits. o Such places as the Suez Canal in Egypt which was controlled by the British provided strategic choke hold over many European powers. o Imperial powers competed over the best potential locations for resources, markets, and trade. History of Imperialism • Ancient Imperialism 600 BCE-500 CE o Roman Empire, Ancient China, Greek Empire, Persian Empire, Babylonian Empire. • Middle Age Imperialism (Age of Colonialism-1400-1800s) o Great Britain, Spain, Portugal, France, Netherlands (Dutch), Russia. • Age of Imperialism 1870-1914 o Great Britain, Spain, Portugal, France, Germany, Belgium, Italy, Japan, United States, Ottoman Empire, Russia. • Current Imperialism...? o U.S. Military intervention (i.e. Middle East) o Russia’s Invasion of Ukraine. Imperialism Colonialism • Refers to political or economic control, either legally or illegally. • Refers to where one nation assumes control over the other. • Creating an empire, expanding into neighboring regions and expanding the dominance far outside its borders. • Where a country conquers and rules over other regions for exploiting resources from the conquered country for the conqueror's benefit. • Foreign government controls/governs a territory without significant settlement. • Foreign government controls/governs the territory from within the land being colonized. • Little to no new settlement established on fresh territory. • Movement to settle to fresh territory. Age of Colonialism WHEN? • Started around the late 1400s and ended around the late 1700s/early 1800s. WHY? • Primary Reason: European countries, wished to find a direct trade route to Asia (China & India) and the East Indies. o Quicker and relatively more effective than land routes over Asia. • Secondary Reason: Empire expansion (land power) WHO? • Countries involved: Great Britain, France, Spain, the Dutch & Portugal. • Individuals’ knowns as Mercantilists believed that maintaining imperialized territory and colonizing the region could serve as a source of wealth, while personal motives by rulers, explorers, and missionaries could therefore promote their own agenda. o This agenda being “Glory, God and Gold”. Mercantilism • Mercantilism was a popular and main economic system for many European nations during the 16th to 18th centuries. • The main goal was to increase a nation’s wealth by promoting government rule of a nation’s economy for the purpose of enhancing state power at the expense of rival national power. • It was the economic counterpart of political absolutism. Why did mercantilists want colonies? • Mercantilists believed that a country must have an excess of exports over imports. • By colonizing territory, it provided the nation with indispensable wealth of precious raw materials. • Therefore, the claimed territory served as a market and supplier of raw materials for the mother country. Which, in time, provided an excess of exports for the nation and thus created wealth. o Development of Trading Companies to support this economic system. Hudson Bay Company – (1670). Controlled primarily North America. o Dutch East Indie Trading Company (1682) o East Indian Trading Company (1600) o Royal African Trade Company (1672) WHERE? • European nations begun to colonize the America, India and the East Indies to create a direct trade route. • Great Britain was the leading power in India, Australia and North America, South Africa. • Spain colonized central and South America. • French held Louisiana, coastal land of Africa and French Guinea. • The Dutch built an empire in the East Indies. • The Portuguese was able to take control of present-day Brazil and the southern tip of South America and Japan. Age of Colonialism • As countries started to imperialize these regions, eventually the concept of colonization took hold: • This is what makes the Age of Colonialism extremely different! End of Colonialism • By 1800, colonialism became less popular • Why? o Revolutions (Spain, France & American) o The Napoleonic Wars o Struggle for nationalism and democracy. o Exhausted all money and energy to supervise their colonies. Waiting to wake again • Imperialism would stay quiet for close to 50 years before Great Britain and France’s economies revitalized. • The outbreak of the Industrial Revolution only encouraged and revitalized European nations to begin their conquest for new territory and resources. Age of Imperialism THE SCRAMBLE FOR AFRICA 1870-1914 Conditions Prior to Imperialism of Africa  European interest in exploiting Africa was minimal.  Their economic interests & profit in Africa primarily came through coastal trade that took place during the 1500-1700s.  The slave trade became the main source of European profit.  Furthermore, disease, political instability, lack of transportation and unpredictable climate all discouraged Europeans from seeking territory. Slave Trade & the Trans-Atlantic Slave Voyages  Forced labor was not uncommon during the 13-17th Centuries. Africans and Europeans had been trading goods and people across the Mediteranea for centuries.  This all changed from 1526 to 1867, as a new system of slavery was introduced that became highly “commercialized, racialized and inherited”  By 1690, the America and West Indies saw approximately 30,000 African people shipped from Africa. A century later, that number grew to 85,000 people per year.  By 1867, approximately 12.5 million people (about twice the population of Arizona) left Africa in a slave ship. What Changed? 1. End of the Slave Trade- Left a need for trade between Europe and Africa. 2. Innovation in technology- The steam engine and iron hulled boats allowed Europe 3. Discovery of new raw materials- Explorers located vast raw materials and resources and this only spurred imperialism with Europe in the wake of the Industrial Revolution. 4. Politics- Unification of Germany and Italy left little room to expand in Europe. Germany and Italy both needed raw materials to “catch up” with Britain and France so they looked to Africa. The Scramble for Africa  The scramble started in 1870.  Although some coastal land had previously been acquired before 1870, the need for territory quickly accelerated as European countries looked t get deeper into Africa.  Within 20 years, nearly all continents were placed under imperialistic rule. Who was Involved?  Great Britain  France  Germany  Italy  Portugal  Belgium  Spain (kind) Violent Affairs  Violence broke out multiple times when European nations looked to claim the same territory.  Germ Chancellor. Otto van Bismarck. Attempted to avert the possibility of violence against the European powers.  In 1884, Bismarck organized a conference in Berlin for the European nations. The Berlin Conference (1884-85)  The conference looked to set ground rules for future annexation of African territory by European Nations.  Annexation is the forcible acquisition and assertion of legal title over one state’s territory by another state, usually following military occupation of the territory.  From a distant perspective, it looked like it would reduce tensions among European nations and avert war.  At the heart of the meeting, these European countries negotiated their claims to African territory, made it official and then mapped their regions.  Furthermore, the leaders agreed to allow free trade among imperialized territory and some homework for negotiating future European claims in Africa was established. Further Path  After the conference, european powers continued to expand their claims in Africa so that by 1900. 90% of the African territory had been claimed. A Turn towards Colonization?  Upon the imperialization of African territory, European nations and little interest in African land unless it produced economic wealth.  Therefore, European governments put little effort and expertise into these imperialized regions.  In most cases, this emat a form of indirect rule. Thus, governing the natin without sufficient settlement and government from within the mother country. Some Exceptions  There were some exemptions through in Africa as colonization was a necessary for some regions i n Africa.  Some regions where diamonds and gold were present. Government looked to protectorate the regions and establish rule and settlement in the regions.  Protectorates: A state controlled and protected by another state for defense against aggression and other law violations. Would  Some examples include South Africa, Botswana, Zimbabwe and Congo. Conclusion  Although it may appear that the Berlin Conference averted war amid the African Scramble, imperialism eventually brought the world into worldwide conflict.  With the continued desire to create an empire by European nations. World War 1 would break out which can be linked to this quest at imperialism.
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I

Hunter's syndrome

Mucopolysaccharidosis 2.

INCIDENCE

  • The condition known as Hunter's syndrome is an example of a defect in the metabolism of the mucopolysaccharides, which are complex sugars. In each of these syndromes, which include Hurler's syndrome, Morquio's syndrome, and San Filippo syndrome, there is a deficiency of a particular enzyme that is responsible for controlling the metabolism of these nutrients. (Other syndromes in this group include San Filippo syndrome.)

  • Hunter's syndrome affects approximately one person in every one hundred thousand live births. Only males have been found to be affected by Hunter syndrome because of the way that it is passed down through generations. It would appear that people of every race on the planet are at risk of being affected by this.

HISTORY

  • Only seven mucopolysaccharide syndromes had been identified up until a relatively recent point in time; each one was brought on by a unique enzyme deficiency.

  • Recent research has led to the discovery of 11 variants, each of which has a flawed ability to metabolize a complex sugar. It is possible that additional enzyme defects similar to those described above will occur.

CAUSATION

  • As a result of the fact that Hunter syndrome is passed down in a manner that is X-linked and recessive, it is never found in females. It is possible for the characteristics to be passed down from mothers to their sons. Iduronate sulphatase is a complicated enzyme that is involved in Hunter's syndrome. This enzyme is responsible for the condition. The absence of this enzyme causes mucopolysaccharides, which are complex sugars, to build up in the organs and tissues of the body. It is these mucopolysaccharides that are responsible for the typical signs and symptoms associated with the syndrome.

  • Using techniques that involve sampling of the chorionic villus, it is possible to diagnose Hunter syndrome at about the ninth week of pregnancy.

CHARACTERISTICS

  • There are two subtypes of Hunter's syndrome; one of these subtypes is less severe than the other, and its progression is less steep overall.

  • The complex sugar that is passed in the urine can be used as a biochemical marker to differentiate between these two different types. The accumulation of this particular sugar in the organs and tissues of the body is what gives rise to the characteristics that are listed below.

  • There does not appear to be any issue with the birth of boys affected by Hunter syndrome.

  • They do not suffer from any abnormalities in their growth and reach all of their developmental milestones at the appropriate times. During these first few days, the only symptom that may be noticeable is noisy breathing, which is typically accompanied by a stuffy or runny nose. However, because this is typically considered to be a natural and healthy part of childhood, nobody pays attention to the fact that there may be other issues at play. The measurements of the child's head circumference fall within the upper limits of what is considered normal for this age range.

  • Umbilical or inguinal hernias are observed in an abnormally high number of infants who are subsequently found to have Hunter syndrome. This is in contrast to the typical incidence of these hernias. Again, boys who do not have Hunter syndrome can still have these weaknesses in the abdominal wall, but because they do not have Hunter syndrome, no one pays attention to them.

  • The facial features begin to take on a more angular and coarse appearance somewhere around the age of two and continue to do so well into adulthood. The boy will have a short neck, and his teeth will appear to be coming through at extremely wide intervals when he is an infant. In addition, over the course of the subsequent months, these characteristics are coupled with a deceleration in the rate of growth.

  • In addition, it is common to observe the body to be covered with a fine, downy hair, which can cause the joints to become stiff.

  • At this point, the accumulation of mucopolysaccharides in the liver and spleen is directly responsible for the enlargement of both of these organs, which takes place at this time. This enlargement may be a contributor to the development of umbilical hernias, as well as their recurrence.

  • Children affected by the mild form of Hunter syndrome have normal intelligence or only a very mild intellectual disability, depending on the severity of the condition. Unfortuitously, when it comes to the severe form, the learning disability is more severe and will become apparent at a younger age, somewhere between the ages of eight and ten.

  • Deposits of mucopolysaccharides can be found in many organs of the body of the boy as he matures, including the heart valves, coronary arteries, meninges, and joints, to name a few of the possible locations. One or more of these complications will lead to an illness in a boy with Hunter's syndrome, which may have a fatal outcome. This could happen as a result of the boy's condition. For instance, damage to the heart valves and/or coronary arteries can lead to heart failure and, in the case of a blocked coronary artery, can result in an unexpected death.

  • Despite the fact that the fundamental genetic and biochemical faults are distinct, the clinical presentation of this condition is strikingly comparable to that of the other mucopolysaccharidoses.

MANAGEMENT IMPLICATIONS

  • Unfortunately, there is no treatment that can completely reverse the effects of Hunter's syndrome. The parents require sensitive counseling regarding the future of their son, and it is essential to place emphasis on the assistance that can be provided to make life as normal as possible for both the child and the parents.

  • Hernias are a condition that can only be fixed through surgical intervention if the abdominal wall is found to be weak. But (as is the case with Hurler's syndrome), there is a high likelihood of recurrence due to further accumulations of mucopolysaccharides, which increase the pressure inside the abdominal wall and push the contents into weakened areas. This is the same mechanism that causes Hurler's syndrome.

  • Children diagnosed with Hunter syndrome need to have their hearing evaluated on a consistent basis. There will need to be distraction tests carried out that are appropriate for the boy's mental age. There is also the possibility of using pure-tone audiometry, with evoked responses serving as an additional diagnostic aid if it is required. Hearing loss is extremely prevalent, and children may require hearing aids as they get older.

  • Physiotherapy is an effective method for minimizing joint contractures, which have the potential to severely restrict range of motion if left untreated. The benefits of hydrotherapy, especially its calming effects, are numerous. Ongoing therapy is recommended, and both the mother and the father should be actively involved in their son's care to the greatest extent that is feasible. Joint deformities can sometimes only be corrected successfully through the use of surgical procedures.

  • Specialized instruction is required for patients with the severe form of Hunter's syndrome who have learning disabilities. It is necessary to perform regular developmental checks in order to keep track of the boy with Hunter's syndrome and ensure that he is developing normally in all aspects. The findings of such monitoring are required before decisions can be made regarding whether or not special educational facilities are required.

  • When dealing with the less severe form of Hunter's syndrome, the typical educational experience is typically satisfactory.

THE FUTURE

  • Children who are affected by the severe form of Hunter's syndrome typically only live into their mid-teens to early twenties. When a person is in their early to middle twenties, the most common cause of death is cardiac problems or a severe respiratory infection.

  • Those who are affected by the less severe form of Hunter's syndrome tend to live longer, and it is not unheard of for patients to reach their late sixties or even seventies.

  • There have been cases of Hunter's syndrome being passed down from fathers to their offspring. Genetic counseling is required for families who have a male child diagnosed with Hunter syndrome. It is possible to identify the females who carry the flawed gene, which is of utmost significance when pondering the possibility of having a child.


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Imperialism Rise in Nationalism • During the French and Industrial Revolution, nationalism continued to inspire nations to increase their political and economic power. • Nationalism became the ideal force in the political, economic, and cultural life in the world, becoming the first universal ideology-organizing all people into a nation state. Nationalism Defined • The strong belief that the interest of a particular nation-state is of primary importance. o Nation-State – a state where the vast majority shares the same culture and is conscious of it. It is an ideal in which cultural boundaries match up with political ones. • As an ideology, it is based on the idea that the individual’s loyalty and devotion to the nation-state surpass other individual/group interests. • Exalting one nation’s belief above all others and placing primary emphasis on promotion of its culture and interests, excluding the interests of others. Changing the World through a Nationalistic Vision • The French Revolution significantly changed the political world and how countries govern. • The Industrial Revolution significantly changed the economic world. • The Age of Imperialism (1870-1914) dramatically changed the political, economic, and social world. What is Imperialism? • Imperialism- The policy of extending the rule of authority of an empire or nation over foreign countries, or of acquiring and holding colonies and dependencies. Power and influence are done through diplomacy or military force. Reasons for Imperialism • There are 5 main motives for empires to seek to expand their rule over other countries or territories: 1. Exploratory • Imperial nations wanted to explore territory unknown to them. • The main purpose for this exploration of new lands was for resource acquisition, medical or scientific research. o Charles Darwin • Other reasons: o Cartography (map making) o Adventure 2. Ethnocentric • Europeans acted on the concept of ethnocentrism o Ethnocentrism- the belief that one race or nation is superior to others. • Ethnocentrism developed out of Charles Darwin’s “survival of the fittest” theory. Philosophers used the theory to explain why there were superior races and inferior races. o This became known as Social Darwinism. • Most imperial nations believed that their cultural values or beliefs were superior to other nations or groups. • Believed imperial conquest would bring successful culture to inferior people. 3. Religious • Imperial expansion promoted a religious movement of people setting out to convert new members of conquered territories. • With the belief that Christianity was superior, missionaries believed it was their duty to spread Christianity to the world. • Christian missionaries established churches, and in doing so, they spread Western culture values as well. • Typically, missionaries spread the imperial nation's language through education and religious interactions. 4. Political • Patriotism and Nationalism helped spur our imperial growth, thus creating competition against other supremacies. • It was a matter of national pride, respect, and security. • Furthermore, European rivalry spurred nations for imperial conquest. Since land equaled power, the more land a country could acquire the more prestige they could wield across the globe. • Empires wanted strategic territory to ensure access for their navies and armies around the world. • The empire believed they must expand, thus they needed to be defended. 5. Economic • With the Industrial Revolution taking place during the same time, governments and private companies contributed to find ways to maximize profits. • Imperialized countries provided European factories and markets with natural resources (old and new) to manufacture products. • Trading posts were strategically placed around imperialized countries to maximize and increase profits. o Such places as the Suez Canal in Egypt which was controlled by the British provided strategic choke hold over many European powers. o Imperial powers competed over the best potential locations for resources, markets, and trade. History of Imperialism • Ancient Imperialism 600 BCE-500 CE o Roman Empire, Ancient China, Greek Empire, Persian Empire, Babylonian Empire. • Middle Age Imperialism (Age of Colonialism-1400-1800s) o Great Britain, Spain, Portugal, France, Netherlands (Dutch), Russia. • Age of Imperialism 1870-1914 o Great Britain, Spain, Portugal, France, Germany, Belgium, Italy, Japan, United States, Ottoman Empire, Russia. • Current Imperialism...? o U.S. Military intervention (i.e. Middle East) o Russia’s Invasion of Ukraine. Imperialism Colonialism • Refers to political or economic control, either legally or illegally. • Refers to where one nation assumes control over the other. • Creating an empire, expanding into neighboring regions and expanding the dominance far outside its borders. • Where a country conquers and rules over other regions for exploiting resources from the conquered country for the conqueror's benefit. • Foreign government controls/governs a territory without significant settlement. • Foreign government controls/governs the territory from within the land being colonized. • Little to no new settlement established on fresh territory. • Movement to settle to fresh territory. Age of Colonialism WHEN? • Started around the late 1400s and ended around the late 1700s/early 1800s. WHY? • Primary Reason: European countries, wished to find a direct trade route to Asia (China & India) and the East Indies. o Quicker and relatively more effective than land routes over Asia. • Secondary Reason: Empire expansion (land power) WHO? • Countries involved: Great Britain, France, Spain, the Dutch & Portugal. • Individuals’ knowns as Mercantilists believed that maintaining imperialized territory and colonizing the region could serve as a source of wealth, while personal motives by rulers, explorers, and missionaries could therefore promote their own agenda. o This agenda being “Glory, God and Gold”. Mercantilism • Mercantilism was a popular and main economic system for many European nations during the 16th to 18th centuries. • The main goal was to increase a nation’s wealth by promoting government rule of a nation’s economy for the purpose of enhancing state power at the expense of rival national power. • It was the economic counterpart of political absolutism. Why did mercantilists want colonies? • Mercantilists believed that a country must have an excess of exports over imports. • By colonizing territory, it provided the nation with indispensable wealth of precious raw materials. • Therefore, the claimed territory served as a market and supplier of raw materials for the mother country. Which, in time, provided an excess of exports for the nation and thus created wealth. o Development of Trading Companies to support this economic system. Hudson Bay Company – (1670). Controlled primarily North America. o Dutch East Indie Trading Company (1682) o East Indian Trading Company (1600) o Royal African Trade Company (1672) WHERE? • European nations begun to colonize the America, India and the East Indies to create a direct trade route. • Great Britain was the leading power in India, Australia and North America, South Africa. • Spain colonized central and South America. • French held Louisiana, coastal land of Africa and French Guinea. • The Dutch built an empire in the East Indies. • The Portuguese was able to take control of present-day Brazil and the southern tip of South America and Japan. Age of Colonialism • As countries started to imperialize these regions, eventually the concept of colonization took hold: • This is what makes the Age of Colonialism extremely different! End of Colonialism • By 1800, colonialism became less popular • Why? o Revolutions (Spain, France & American) o The Napoleonic Wars o Struggle for nationalism and democracy. o Exhausted all money and energy to supervise their colonies. Waiting to wake again • Imperialism would stay quiet for close to 50 years before Great Britain and France’s economies revitalized. • The outbreak of the Industrial Revolution only encouraged and revitalized European nations to begin their conquest for new territory and resources. Age of Imperialism THE SCRAMBLE FOR AFRICA 1870-1914 Conditions Prior to Imperialism of Africa  European interest in exploiting Africa was minimal.  Their economic interests & profit in Africa primarily came through coastal trade that took place during the 1500-1700s.  The slave trade became the main source of European profit.  Furthermore, disease, political instability, lack of transportation and unpredictable climate all discouraged Europeans from seeking territory. Slave Trade & the Trans-Atlantic Slave Voyages  Forced labor was not uncommon during the 13-17th Centuries. Africans and Europeans had been trading goods and people across the Mediteranea for centuries.  This all changed from 1526 to 1867, as a new system of slavery was introduced that became highly “commercialized, racialized and inherited”  By 1690, the America and West Indies saw approximately 30,000 African people shipped from Africa. A century later, that number grew to 85,000 people per year.  By 1867, approximately 12.5 million people (about twice the population of Arizona) left Africa in a slave ship. What Changed? 1. End of the Slave Trade- Left a need for trade between Europe and Africa. 2. Innovation in technology- The steam engine and iron hulled boats allowed Europe 3. Discovery of new raw materials- Explorers located vast raw materials and resources and this only spurred imperialism with Europe in the wake of the Industrial Revolution. 4. Politics- Unification of Germany and Italy left little room to expand in Europe. Germany and Italy both needed raw materials to “catch up” with Britain and France so they looked to Africa. The Scramble for Africa  The scramble started in 1870.  Although some coastal land had previously been acquired before 1870, the need for territory quickly accelerated as European countries looked t get deeper into Africa.  Within 20 years, nearly all continents were placed under imperialistic rule. Who was Involved?  Great Britain  France  Germany  Italy  Portugal  Belgium  Spain (kind) Violent Affairs  Violence broke out multiple times when European nations looked to claim the same territory.  Germ Chancellor. Otto van Bismarck. Attempted to avert the possibility of violence against the European powers.  In 1884, Bismarck organized a conference in Berlin for the European nations. The Berlin Conference (1884-85)  The conference looked to set ground rules for future annexation of African territory by European Nations.  Annexation is the forcible acquisition and assertion of legal title over one state’s territory by another state, usually following military occupation of the territory.  From a distant perspective, it looked like it would reduce tensions among European nations and avert war.  At the heart of the meeting, these European countries negotiated their claims to African territory, made it official and then mapped their regions.  Furthermore, the leaders agreed to allow free trade among imperialized territory and some homework for negotiating future European claims in Africa was established. Further Path  After the conference, european powers continued to expand their claims in Africa so that by 1900. 90% of the African territory had been claimed. A Turn towards Colonization?  Upon the imperialization of African territory, European nations and little interest in African land unless it produced economic wealth.  Therefore, European governments put little effort and expertise into these imperialized regions.  In most cases, this emat a form of indirect rule. Thus, governing the natin without sufficient settlement and government from within the mother country. Some Exceptions  There were some exemptions through in Africa as colonization was a necessary for some regions i n Africa.  Some regions where diamonds and gold were present. Government looked to protectorate the regions and establish rule and settlement in the regions.  Protectorates: A state controlled and protected by another state for defense against aggression and other law violations. Would  Some examples include South Africa, Botswana, Zimbabwe and Congo. Conclusion  Although it may appear that the Berlin Conference averted war amid the African Scramble, imperialism eventually brought the world into worldwide conflict.  With the continued desire to create an empire by European nations. World War 1 would break out which can be linked to this quest at imperialism.
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Hunter's syndrome

Mucopolysaccharidosis 2.

INCIDENCE

  • The condition known as Hunter's syndrome is an example of a defect in the metabolism of the mucopolysaccharides, which are complex sugars. In each of these syndromes, which include Hurler's syndrome, Morquio's syndrome, and San Filippo syndrome, there is a deficiency of a particular enzyme that is responsible for controlling the metabolism of these nutrients. (Other syndromes in this group include San Filippo syndrome.)

  • Hunter's syndrome affects approximately one person in every one hundred thousand live births. Only males have been found to be affected by Hunter syndrome because of the way that it is passed down through generations. It would appear that people of every race on the planet are at risk of being affected by this.

HISTORY

  • Only seven mucopolysaccharide syndromes had been identified up until a relatively recent point in time; each one was brought on by a unique enzyme deficiency.

  • Recent research has led to the discovery of 11 variants, each of which has a flawed ability to metabolize a complex sugar. It is possible that additional enzyme defects similar to those described above will occur.

CAUSATION

  • As a result of the fact that Hunter syndrome is passed down in a manner that is X-linked and recessive, it is never found in females. It is possible for the characteristics to be passed down from mothers to their sons. Iduronate sulphatase is a complicated enzyme that is involved in Hunter's syndrome. This enzyme is responsible for the condition. The absence of this enzyme causes mucopolysaccharides, which are complex sugars, to build up in the organs and tissues of the body. It is these mucopolysaccharides that are responsible for the typical signs and symptoms associated with the syndrome.

  • Using techniques that involve sampling of the chorionic villus, it is possible to diagnose Hunter syndrome at about the ninth week of pregnancy.

CHARACTERISTICS

  • There are two subtypes of Hunter's syndrome; one of these subtypes is less severe than the other, and its progression is less steep overall.

  • The complex sugar that is passed in the urine can be used as a biochemical marker to differentiate between these two different types. The accumulation of this particular sugar in the organs and tissues of the body is what gives rise to the characteristics that are listed below.

  • There does not appear to be any issue with the birth of boys affected by Hunter syndrome.

  • They do not suffer from any abnormalities in their growth and reach all of their developmental milestones at the appropriate times. During these first few days, the only symptom that may be noticeable is noisy breathing, which is typically accompanied by a stuffy or runny nose. However, because this is typically considered to be a natural and healthy part of childhood, nobody pays attention to the fact that there may be other issues at play. The measurements of the child's head circumference fall within the upper limits of what is considered normal for this age range.

  • Umbilical or inguinal hernias are observed in an abnormally high number of infants who are subsequently found to have Hunter syndrome. This is in contrast to the typical incidence of these hernias. Again, boys who do not have Hunter syndrome can still have these weaknesses in the abdominal wall, but because they do not have Hunter syndrome, no one pays attention to them.

  • The facial features begin to take on a more angular and coarse appearance somewhere around the age of two and continue to do so well into adulthood. The boy will have a short neck, and his teeth will appear to be coming through at extremely wide intervals when he is an infant. In addition, over the course of the subsequent months, these characteristics are coupled with a deceleration in the rate of growth.

  • In addition, it is common to observe the body to be covered with a fine, downy hair, which can cause the joints to become stiff.

  • At this point, the accumulation of mucopolysaccharides in the liver and spleen is directly responsible for the enlargement of both of these organs, which takes place at this time. This enlargement may be a contributor to the development of umbilical hernias, as well as their recurrence.

  • Children affected by the mild form of Hunter syndrome have normal intelligence or only a very mild intellectual disability, depending on the severity of the condition. Unfortuitously, when it comes to the severe form, the learning disability is more severe and will become apparent at a younger age, somewhere between the ages of eight and ten.

  • Deposits of mucopolysaccharides can be found in many organs of the body of the boy as he matures, including the heart valves, coronary arteries, meninges, and joints, to name a few of the possible locations. One or more of these complications will lead to an illness in a boy with Hunter's syndrome, which may have a fatal outcome. This could happen as a result of the boy's condition. For instance, damage to the heart valves and/or coronary arteries can lead to heart failure and, in the case of a blocked coronary artery, can result in an unexpected death.

  • Despite the fact that the fundamental genetic and biochemical faults are distinct, the clinical presentation of this condition is strikingly comparable to that of the other mucopolysaccharidoses.

MANAGEMENT IMPLICATIONS

  • Unfortunately, there is no treatment that can completely reverse the effects of Hunter's syndrome. The parents require sensitive counseling regarding the future of their son, and it is essential to place emphasis on the assistance that can be provided to make life as normal as possible for both the child and the parents.

  • Hernias are a condition that can only be fixed through surgical intervention if the abdominal wall is found to be weak. But (as is the case with Hurler's syndrome), there is a high likelihood of recurrence due to further accumulations of mucopolysaccharides, which increase the pressure inside the abdominal wall and push the contents into weakened areas. This is the same mechanism that causes Hurler's syndrome.

  • Children diagnosed with Hunter syndrome need to have their hearing evaluated on a consistent basis. There will need to be distraction tests carried out that are appropriate for the boy's mental age. There is also the possibility of using pure-tone audiometry, with evoked responses serving as an additional diagnostic aid if it is required. Hearing loss is extremely prevalent, and children may require hearing aids as they get older.

  • Physiotherapy is an effective method for minimizing joint contractures, which have the potential to severely restrict range of motion if left untreated. The benefits of hydrotherapy, especially its calming effects, are numerous. Ongoing therapy is recommended, and both the mother and the father should be actively involved in their son's care to the greatest extent that is feasible. Joint deformities can sometimes only be corrected successfully through the use of surgical procedures.

  • Specialized instruction is required for patients with the severe form of Hunter's syndrome who have learning disabilities. It is necessary to perform regular developmental checks in order to keep track of the boy with Hunter's syndrome and ensure that he is developing normally in all aspects. The findings of such monitoring are required before decisions can be made regarding whether or not special educational facilities are required.

  • When dealing with the less severe form of Hunter's syndrome, the typical educational experience is typically satisfactory.

THE FUTURE

  • Children who are affected by the severe form of Hunter's syndrome typically only live into their mid-teens to early twenties. When a person is in their early to middle twenties, the most common cause of death is cardiac problems or a severe respiratory infection.

  • Those who are affected by the less severe form of Hunter's syndrome tend to live longer, and it is not unheard of for patients to reach their late sixties or even seventies.

  • There have been cases of Hunter's syndrome being passed down from fathers to their offspring. Genetic counseling is required for families who have a male child diagnosed with Hunter syndrome. It is possible to identify the females who carry the flawed gene, which is of utmost significance when pondering the possibility of having a child.