Oxygen Transport
Carried by erythrocytes (red blood cells) produced in bone marrow.
Synthesis regulated by erythropoietin (hormone from kidneys).
Cell Types and Tissues
Four Major Classes:
Neurons
Muscle Cells
Epithelial Cells
Connective Tissue Cells
Specialized to contract and generate force.
Types:
Skeletal Muscle: Voluntary movements (arms, legs).
Cardiac Muscle: Involuntary (heart).
Smooth Muscle: Involuntary (blood vessels).
Form continuous layers found in skin and linings of hollow organs (lungs, stomach, intestines).
Specialized for exchange and separation from the environment.
Variations in Shape:
Simple: One cell thick.
Stratified: Several cells thick.
Squamous: Flattened.
Cuboidal: Square-shaped.
Columnar: Tall and oblong.
Form barriers; prevent mixing of materials.
Transport Functions:
Stomach cells transport hydrogen ions (acid) into the lumen for digestion.
Gland Formation:
Exocrine Glands: Secrete substances externally (sweat, saliva).
Endocrine Glands: Secrete hormones (e.g., pituitary gland).
Provides support and anchors various structures.
Examples:
Tendons: Anchor muscles to bones.
Ligaments: Connect bones.
Elastic Tissue: Provides flexibility (e.g., skin).
Extracellular Matrix:
Composed of proteins (elastin, collagen) and large molecules to support cells.
Types of Tissues:
Nervous Tissue
Muscle Tissue
Epithelial Tissue
Connective Tissue
Organ Systems:
Organs are made up of two or more tissue types performing specific functions (e.g., cardiovascular system includes heart, blood vessels).
Lungs:
Inspiration: Oxygen enters bloodstream.
Expiration: CO2 exits.
Gastrointestinal Tract:
Absorption: Nutrients and fluids from digested food into bloodstream.
Total Body Water: Comprises intracellular fluid (ICF) and extracellular fluid (ECF).
ICF: ⅔ total body water, rich in potassium and protein.
ECF: ⅓ total body water, includes plasma and interstitial fluid (ISF). Rich in sodium.
Homeostasis:
Internal environment regulated for stability (composition, temperature, volume).
Negative Feedback:
Regulated variables: Control variables returned to set point (e.g., temperature regulation).
Sensors and Integrators:
Chemoreceptors (sensitive to O2 and CO2) and thermoreceptors (sensitive to temperature).
Relay signals to integrating centers, which orchestrate responses.
Passive Transport:
Movement from high to low energy areas without energy input.
Simple diffusion of solutes according to concentration gradient.
Active Transport:
Movement from low to high concentration needing energy input (e.g., Na+/K+ pump).
Chemical Driving Forces:
Always move down concentration gradients.
Electrical Driving Forces:
Difference in charge affecting ion movement.
Hormones control physiological processes by regulating metabolic functions in target cells.
Hypothalamus:
Regulates autonomic functions and produces hormones affecting pituitary gland.
Pituitary Gland:
Anterior lobe: Epithelial tissue, synthesizes hormones.
Posterior lobe: Neuronal tissue, secretes ADH and oxytocin.
Thyroid Gland:
Secretes T3 and T4, regulates metabolism.
Adrenal Glands:
Cortex secretes corticosteroids; medulla secretes catecholamines.
Short and Long Loop Feedback:
Regulate hormone secretion to maintain balance in the body.
Dual Innervation:
Sympathetic (fight or flight) and Parasympathetic (rest and digest).
Regulates effector organ functions to maintain homeostasis.
Acetylcholine (cholinergic) and Norepinephrine (adrenergic) are main neurotransmitters regulating autonomic functions.
Visceral Reflexes:
Autonomic responses to internal body conditions, modulated by the brain.
Understanding these physiological concepts is critical for grasping the complexity of body systems and their interactions.