Emotion refers to a conscious brain function subjectively experienced as a strong feeling directed toward a specific object, typically accompanied by physiological and behavioral changes.
Described as complex, it encompasses various responses influenced by biological components and experiences.
Structures involved include the amygdala, hypothalamus, and the prefrontal cortex.
These regions interact with each other to regulate emotional responses and behaviors.
The amygdala, in particular, plays a critical role in processing emotions such as fear and pleasure.
The amygdala receives sensory input and coordinates emotional responses, recognizing threats and forming emotional memories.
An increase in amygdala activity can lead to amplified emotional reactions, while atrophy can reduce fear responses—as seen in patient SM with amygdala damage.
Basic neural mechanisms involve synaptic plasticity, allowing the brain to adapt to new information and experiences emotionally.
Receptor function, particularly involving glutamate receptors, supports the expression of emotions through processes like long-term potentiation (LTP) which enhances synaptic strength.
Knowledge of emotional pathways can guide treatments for affective disorders, such as anxiety or depression, by targeting specific neural circuits and receptors involved in emotional regulation.
Example: Managing anxiety by enhancing inhibition and dampening excessive amygdala activity through pharmacological intervention.
Tiffany Watt Smith: The History of Human Emotions | TED Talk
Background reading: Emotion (Chapters 29 & 30 in Editions), Neuroscience by Purves et al.
Importance of connecting current knowledge with previous insights to enhance learning.
Six basic emotions identified: Fear, Anger, Joy, Sadness, Surprise, and Disgust.
A complex palette of 154 human emotions results from biological interactions among these basic emotions, adding layers of complexity in feelings (e.g., Gezelligheit, Wunderlust).
Emotions are heavily context-dependent and influenced by memory, as demonstrated by associations made in various situations (e.g., nostalgic feelings tied to experiences).
Evolutionary perspective: Emotional responses evolved to offer advantages, such as responding to threats (e.g., feeling fear when faced with danger like a lion) or social bonding (e.g., feelings of love).
Emotional stimuli processed by sensory systems trigger emotional systems (e.g., the hypothalamus).
Responses involve complex interactions between somatic responses (behaviors) and autonomic systems regulating physiological changes (e.g., heart rate).
Studies identify the diencephalon as central to emotional expression, evidenced by transection experiments showing the effects on emotional responses.
Higher regulatory centers in the brain coordinate voluntary movement and emotional expression via sensory and emotional pathways, influencing motor neurons that control bodily expressions.
The limbic system, historically known as the limbic lobe, includes structures like the cingulate gyrus, hippocampus, and amygdala, involved in processing emotional responses.
Conditioning demonstrates how emotional responses can be learned through associations between different sensory inputs (e.g., sound associated with an electric shock) that strengthen synaptic pathways.
Emotions depend on context and can change dynamically, influenced by immediate experiences shaped through memory and associative learning.
The amygdala and hippocampus play critical roles in managing emotional recollections and reactions based on stimulus triggers.
Beyond fear, positive emotional experiences (e.g., love) are illustrated through brain imaging studies showing differences in brain activity when viewing familiar loved ones.
Composed of four subunits, glutamate receptors are pivotal in excitatory synaptic transmission.
Glycine receptors (anions) also play a role in neurotransmission; both are essential in modulating emotional states.
Affective disorders such as anxiety and depression represent dysfunctional emotional states that can be targeted for treatment.
Therapeutic approaches focus on normalizing emotional responses by modifying pathways affecting fear and anxiety, impacting the amygdala and associated circuits.