The activation energy is the potential energy of the transition state, minus the potential energy of the reactants.
Enzymes work in 2 ways: lowering the energy of the transition state, or form a new reaction intermediate, thus providing a new mechanism that has a lower activation energy.
Each enzyme connects with a specific molecule called a substrate.
The substrate binds to a part of an enzyme called the active site.
A reaction is catalyzed only after the enzyme-substrate complex is formed, which lowers the the energy of the transition state, also called stabilizing it.