Blood
Transports oxygen, waste, and hormones
Regulates body temperature, pH and fluid volume
Prevents infection and blood loss
Suspended cells are known as formed elements
Fluid matrix is known as plasma
Hematocrit= % of red blood cells
Plasma: 55%, WBC: 1%, RBC:44%
Plasma= 90% water, 10% dissolved gas..etc.
3 types of proteins
Albumin- regulates osmosis between blood + tissues
Globins- Transports substances to fight infections
Fibrogen- used in blood clotting
Composition of plasma is regulated by homeostais
Function of RBC: transport oxygen around the body via hemoglobin molecules
Oxygen is non polar so it can’t diffuse into the blood
RBC
Very numerous
Live 100-120 days
Confined to the blood
Constants concentration
Vs.
WBC
Less numerous
Pass out of the blood (diapedesis)
Concentration fluctuates
Live a few days to a few years
Granulocytes: Neutrophils: Engulf and destroy bacteria , Basophils: dilate blood to help WBC to get to allergen faster, Eosinophils: kill parasitic worms in foods
Agranulocytes: Lymphocytes: T- cells and B- cells, Monocytes: become macrophages
Platelets function: Cutting the blood when a vessel is broken
Blood processes
All formed elements are from a common cell (hemocytoblast)
Hemocytoblasts differente into lymphoid stem cells which create lymphocytes and myeloid stem cells which create all other types of blood cells
Hormones
RBC= erythropoietin
WBC= CSF + Interleukins
Platelets= thrombopoietin
Blood clot= when a vessel is injured
Blood vessel contracts, reducing blood loss at the wound
Platelets are chemically attracted to wounded epithelium + stick together
Injured tissues releases tissues doctor
Thrombin + Fibrinogen= Fibrin Mesh
Abnormal clot restricts the flow of blood causing stroke, heart attack, and or death
Blood groups
Antigen: substance that blood recognizes as foreign
As antibodies blind they clump = agglutination (all plasmas clump)
A can donate or A or AB
B can do donate to B or AB
AB can ONLY donate to AB
O can donate to all
Anti Rh antibodies are not produced immediately
** Moms can start to have pregnancies against future babies
Heart
Apex= left hip
Outer covering
Fibrous pericardium: Provides protection and anchors heart in place
Parietal Pericardium: Lubricates & reduce friction
Visceral Pericardium: Lubricates & reduce friction
Walls
Epicardium
Myocardium
Endocardium
Pulmonary circuit- carries blood to lungs pick up O2 + drop off Co2
Systemic- Carries blood to body tissues drop off O2 + pick up CO2
Four chambers
Right atrium + left atrium
Right ventricle + left ventricle
Oxygenated: Left atrium and left ventricle
Deoxygenated: Right atrium + right ventricle
cover atria= auricles
AV valves: between atria and ventricles (Tricuspid + Bicuspid)
Semilunar valves: between the ventricles and major blood vessels (pulmonary + aortic)
SA node= cardiac pacemaker
Diastole: Relax
Atrial contraction ventricles fill
Av valves close making lub sound
Isometric relaxation
Systole (contraction)
Isometric contraction of ventricle
Ejection phase
Selumlanr values close (dub sound)
Cardiac output= amount of blood pumped by each ventricle per minute (Heart rate x stroke volume)
Stroke volume: blood pumped out by a ventricle in a heartbeat (exercise)
Heart rate: Number of times the heart beats per minute (stress, hormones)