Adaptor protein: a type of protein that helps to bring other proteins or molecules together in a specific way.
COPI-coated vesicle: a type of transport vesicle that is coated with a protein called COPI (coat protein complex I). COPI-coated vesicles are involved in the movement of proteins and other molecules between the endoplasmic reticulum (ER) and the Golgi apparatus.
Rab effector: a type of protein that interacts with and is regulated by Rab proteins. Rab effectors help to control the movement of transport vesicles and other organelles within cells.
ARF protein: a type of GTPase (a type of protein that can bind and hydrolyze GTP) called ADP-ribosylation factor. ARF proteins are involved in the movement of proteins and other molecules between the endoplasmic reticulum (ER) and the Golgi apparatus.
COPII-coated vesicle: a type of transport vesicle that is coated with a protein called COPII (coat protein complex II). COPII-coated vesicles are involved in the movement of proteins and other molecules between the endoplasmic reticulum (ER) and the Golgi apparatus.
Rab protein: a type of GTPase (a type of protein that can bind and hydrolyze GTP) that plays a key role in the movement of transport vesicles within cells. Rab proteins bind to and regulate the activity of other proteins, including Rab effectors, to control the movement of transport vesicles and other organelles.
Cargo: the molecules or proteins that are carried by transport vesicles. Cargo can include proteins, lipids, and other molecules that are destined for different parts of the cell or for the extracellular space.
Dynamin: a type of protein that is involved in the process of endocytosis, which is the internalization of plasma membrane components and the uptake of small particles and nutrients. Dynamin helps to form and pinch off clathrin-coated vesicles from the plasma membrane.
Sar1 protein: a type of GTPase (a type of protein that can bind and hydrolyze GTP) that is involved in the formation of COPII-coated vesicles. Sar1 proteins help to initiate the budding of COPII-coated vesicles from the endoplasmic reticulum (ER).
SNARE protein (SNARE): a type of protein that plays a key role in the process of exocytosis, which is the release of vesicle contents to the extracellular space or plasma membrane. SNARE proteins mediate the fusion of transport vesicles with their target membranes.
Clathrin: a protein that forms a lattice-like structure on the surface of clathrin-coated vesicles. Clathrin helps to mediate the internalization of plasma membrane components and the uptake of small particles and nutrients through a process called clathrin-mediated endocytosis.
· "Dynamin" is a protein that helps to pinch off clathrin-coated vesicles from the plasma membrane during clathrin-mediated endocytosis.
· "Lumen" refers to the interior space of a membrane-enclosed compartment or organelle.
· "NSF" stands for "N-ethylmaleimide-sensitive factor," which is a protein that helps to facilitate the fusion of transport vesicles with their target membranes.
· "Phosphatidylinositide" (PIP) refers to a type of lipid molecule that is important in the regulation of vesicular transport.
· "Rab protein" is a type of small GTPase that helps to direct transport vesicles to the correct target membrane and to regulate the fusion of transport vesicles with their target membranes.
· "Sar1 protein" is a type of small GTPase that plays a role in the budding of transport vesicles from the endoplasmic reticulum (ER).
· "SNARE protein" (SNARE) stands for "soluble NSF attachment protein receptor," which refers to a group of proteins that help to facilitate the fusion of transport vesicles with their target membranes. There are two main types of SNARE proteins: t-SNAREs, which are present on the target membrane, and v-SNAREs, which are present on transport vesicles.
· "Rab cascade" refers to a series of sequential steps in which different Rab proteins are activated and direct transport vesicles to the correct target membrane.