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Home
Science
Biology
Genetics
DNA Repair
DNA Repair Mechanisms
Direct chemical reversal of the damage
Excision repair
: damaged base or bases are removed and then replaced with the correct ones
Base Excision Repair
Nucleotides Excision Repair
Mismatch Repair
Base Excision Repair
DNA glycosylase removes the damaged base
Occurs about 20,000 times a day in every cell
Removal of its deoxyribose phosphate
Produces a gap
Correct nucleotide is incorporated by DNA polymerase β
Ligation
Nucleotide Excision Repair
The damage is recognized by one or more protein factors that assemble at the location.
The DNA is unwound producing a "bubble".
Cuts are made on both the 3’ side and the 5’ side of the damaged area and the tract containing the damage can be removed
Using the opposite strand as a template DNA Pol α or ε fills in the correct nucleotides
This is followed by Ligation
Nucleotide-excision repair proceeds most rapidly on the DNA strand that is serving as the template for transcription
Mismatch Repair
Mismatch repair deals with correcting mismatches of the normal bases
Accounts for 99% of all repairs
Follows behind replication fork
Recognition of mismatch require protein complex
Excision of mismatch
DNA synthesis by Pol 𝛼 or 𝜀
Repairing Strand Breaks
Single-Strand Breaks
: uses the same enzyme systems that are used in base excision repair
Double-Strand Breaks
Nonhomologous End Joining = Direct joining of the broken ends
Nonhomologous Recombination
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