Results in proteinuria and hematuria, potentially leading to kidney failure and dialysis.
Systemic Lupus Interventions
NSAIDs and corticosteroids (long-term use leads to moon face and buffalo hump).
Antimalarial drugs (hydroxychloroquine) for fatigue and joint pain.
Immunosuppressant drugs.
Patient education: rest, avoid warm environments.
Scleroderma
Disorder of the connective tissue causing fibrosis or degenerative inflammatory changes in skin, blood vessels, synovium, skeletal muscle, and internal organs.
Connective tissue around organs becomes stiff, impairing function.
Stiffening of connective tissue around the mouth can affect eating.
Onset between 30-50 years; more common in women.
Two types: crest form (benign) and diffuse form (rapidly progresses to widespread organ involvement).
Treatment: physical and occupational therapy, drug therapy.
Scleroderma Interventions
Vasoactive agents and calcium channel blockers early in the disease.