KG

Cell Communication & Receptor Families

Cell Communication

Cell Communication Importance

  • Essential for body function, environmental sensing, and response.
  • Understanding it is crucial because:
    • Disorders can lead to diseases (e.g., nervous and endocrine system).
    • Most drugs act by modifying cell-to-cell communication.

Types of Cell Signaling

  • Local Signaling:
    • Paracrine: signaling molecule acts on nearby cells (e.g., immune responses).
    • Synaptic: communication between neurons (e.g., thoughts and memories).
  • Long Distance Signaling:
    • Endocrine: hormone released into bloodstream, travels to target cell (e.g., insulin).

Cell Signaling Stages

  1. Reception: signaling molecule binds to receptor.
  2. Transduction: signaling pathway initiated.
  3. Response: cellular response activated (e.g., enzyme activation).

Receptors

  • Proteins that bind to signaling molecules (ligands/agonists) to elicit a response.
  • Hydrophilic molecule receptors are on the cell surface.
  • Hydrophobic molecule receptors are intracellular.
  • Transduction pathway and response depend on receptor type and cell type.

Receptor Families

  1. Ligand-gated ion channels
  2. G protein-coupled receptors
  3. Tyrosine kinase receptors
  4. Steroid receptors

Neurotransmission Receptors

  1. Ligand-gated ion channels:
    • Fast, direct neurotransmission.
    • Ions flow into/out of cell, changing membrane voltage (IPSPs and EPSPs).
  2. G protein-coupled receptors:
    • Slower, indirect neurotransmission.
    • Activation modifies depolarization or hyperpolarization.

G Protein-Coupled Receptors

  • Large family; many drug targets.
  • Activation causes a cascade of effects.
  • Phosphorylation (addition of phosphate groups by kinases) controls protein activity.
  • Dephosphorylation (removal of phosphate groups by phosphatases) also controls protein activity.
  • Amplification enables pronounced cellular response from low neurotransmitter concentrations.

Neurotransmitters

  • Effect depends on receptors expressed by the postsynaptic cell.

Tyrosine Kinase Receptors

  • Membrane receptors responding to hormones.
  • Important for metabolism and growth.
  • Receptor dimerization leads to autophosphorylation and activation of other proteins.
  • Often involves phosphorylation cascades leading to gene transcription.

Steroid Receptors

  • Intracellular receptors for lipophilic hormones.
  • Translocation to nucleus, triggers gene transcription (slow process).