(1) Methylation | The Top 4 Supplements & How To Use Them.

Introduction to Methylation Treatments

• Dr. Robin Lewis is a naturopathic physician in Vancouver, BC.

• This video is part two of a series focused on methylation, outlining treatments for poor methylation.

• Viewers are encouraged to watch part one for foundational knowledge on methylation.

• Emphasis on low methylation; high methylation is usually due to overuse of supplements.

Key Supplements for Methylation

• Focus on the top four supplements commonly associated with methylation treatments:

  • B9 (Folate/Folic Acid)

    • Genetic variations, especially in the MTHFR gene, affect B9 activation.

    • Activated B9 is crucial for recycling homocysteine (cardiovascular health) and regenerating SAMe.

    • Requires adequate B12 for effective functioning; can cause side effects without sufficient B12 (e.g., anxiety, insomnia).

    • Dosage depends on deficiency levels, gene variations, dietary intake, and is typically between 400-1200 mcg.

    • Sources include leafy greens, fruits, meat, eggs; be cautious with enriched foods as they often contain inactive forms (folic acid).

  • B12

    • Common deficiency, especially in plant-based diets; also affected by certain medications.

    • Deficiency symptoms include fatigue, low mood, and nervous system issues.

    • Recommended to supplement with B12 before taking activated B9 to build levels (typically 100-1500 mcg daily).

    • Available in methylated (methylcobalamin) and unmethylated forms (cyanocobalamin, adenosylcobalamin).

  • SAMe (S-adenosylmethionine)

    • Produced when B9 and B12 are sufficient; involved in methylating DNA and producing neurochemicals.

    • Supports detoxification by regenerating glutathione.

    • Commonly used for osteoarthritis and depression; dosages typically range from 800-1600 mg daily.

    • Risks include overstimulation and potential mania, not recommended for bipolar disorder.

  • Bane (Trimethylglycine)

    • Functions as a methyl donor and helps reduce homocysteine levels.

    • Shows promise in research related to liver disease, improving antioxidant status and inflammatory markers.

    • In studies, 20 grams daily improved liver damage outcomes in patients with non-alcoholic liver disease (NASH).

Conclusion

• Caution is emphasized in supplement usage to avoid side effects; dosage should be individualized based on needs and professional guidance.

• The impact of these supplements can be significant if used appropriately.