Experimental Design in Neuro

  • Case studies
    • identifying interesting events that occurred naturally to develop hypotheses
    • Phillip Gage
    • Oliver
  • Screens
    • performing unbiased searches for anatomical structures, neurons, proteins, genes, or mutations that could play a role in behavior/phenotype of interest
    • Genome wide GWAS - screening technique used to
  • Description
    • w/ out manipulation
    • Santiago Romani Kaho - used stinning technique to show shapes of diff. neurons
  • Manipulation
    • manipulating IV and viewing effects of IV on DV
    • loss of function necessary
    • rescue experiment - return sythetic version of trait that was deleted
    • gain of function is sufficient
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