• Staphylococcus epidermidis

  • coagulase negative

  • Only pathogenic when skin is broken

  • Can penetrate skin via catheter insertion

  • nosocomial pathogen

  • possess slime layer

• Staphylococcus aureus

  • Most pathogenic of the staphylococci

  • form Golden-yellow colonies which protects against the microbial effects of sunlight

  • Coagulase positive

  • possesses a number of virulence factors:

    • Toxins: anti-phagocytic

    • Resists opsonization

    • Neutralizes AMPS of host

    • Lysozyme resistant

    • Antibiotic resistant (MRSA,VRSA)

    • Causes:

      • Folliculitis - Infection of the hair follicles

      • Sty - folliculitis of an eyelash

      • Furuncle (boil) - abscess; pus surrounded by inflamed tissue

      • Carbuncle - Inflammation of tissue under the skin

      • Impetigo - crusting (nonbullous) sores, spread by autoinoculation

      • Scalded skin syndrome (bullous): form of impetigo due to toxins; causes separation of skin layer

• Streptococcus pyogenes

• Streptococcus pneumoniae

• Streptococcus mutans

• Herpesvirus Varicella-Zoster

• Neisseria meningitidis

• Listeria monocytogenes

• Clostridium tetani

• Clostridium botulinum

• Rabies virus

• Yersinia pestis

• Legionella pneumophila

• Bordetella pertussis

• Corynebacterium diphtheria

• Shigella dysenteriae

• E coli

• Salmonella enterica

• Rotavirus

• Giardia lamblia

• Treponema pallidum

Know:

 Gram reaction (where applicable)

 Cellular morphology

 Disease caused by pathogen

 Distinguishing features of the

disease, e.g., important virulence

factor(s) of pathogen or life cycle