Pure Food and Drug Act (1906): First law to regulate drug quality and labeling.
Federal Food, Drug, and Cosmetic Act (1938): Required safety testing before marketing.
Controlled Substances Act (1970): Classified drugs into five schedules based on abuse potential.
FDA (Food and Drug Administration): Regulates drug approval, safety, and marketing.
DEA (Drug Enforcement Administration): Monitors controlled substances and drug enforcement.
Pharmacology: Study of drugs and their effects on the body.
Drug Nomenclature:
Chemical Name – Describes the drug’s chemical structure.
Generic Name – Official name, not owned by any company (e.g., acetaminophen).
Trade Name – Brand name given by the manufacturer (e.g., Tylenol).
Types of Drug Preparations:
Oral (tablet, capsule, syrup)
Topical (cream, patch)
Parenteral (IV, IM, SC)
Inhalation (inhaler, nebulizer)
Pharmacokinetics – How the body acts on a drug (ADME):
Absorption – How the drug enters the bloodstream.
Distribution – How the drug is transported to tissues.
Metabolism – How the body breaks down the drug (liver).
Excretion – How the drug is removed from the body (kidneys).
Pharmacodynamics – How the drug affects the body:
Receptor binding → cellular response.
Allergic effect – Immune response (rash, hives).
Anaphylactic reaction – Severe allergic reaction (difficulty breathing, hypotension).
Idiosyncratic effect – Unusual or unexpected reaction.
Toxic effects – Harmful effects due to drug buildup.
Drug tolerance – Decreased response over time.
Age, weight, genetics, sex, organ function, interactions with other drugs.
PRN order – Given as needed.
Stat order – Given immediately.
Routine order – Given at regular intervals.
Single order – Given once.
Ensure accuracy using dimensional analysis or ratio/proportion.
"Rights" of Medication Administration:
Right patient
Right drug
Right dose
Right route
Right time
Right documentation
Current medications
Allergies
Past adverse reactions
OTC medications and supplements
Substance use history
Swallowed, absorbed in the GI tract.
Ensure patient can swallow; do not crush extended-release tablets.
Intramuscular (IM): Into muscle (90-degree angle).
Subcutaneous (SC): Into fat layer (45-degree angle).
Intradermal: Into the dermis (15-degree angle).
Intravenous (IV): Directly into bloodstream.
Apply to skin or mucous membranes.
Avoid contact with open wounds unless indicated.
Absorbed through lungs (rapid effect).
Assessment: Patient history, allergies, lab values.
Diagnosis: Identify potential medication issues.
Planning: Identify goals and outcomes.
Implementation: Administer medication using the "Rights" of administration.
Evaluation: Assess patient response and side effects.
Purpose of medication
How and when to take it
Side effects to report
Drug interactions
Storage and handling
Addiction: Dependence on a substance (physical/psychological).
Pharmacology: Study of drugs and their actions.
Clinical Decision Making: Judging the best course of action based on patient needs.
Safety: Following protocols to avoid medication errors.
Term | Definition |
Absorption | Process by which a drug enters the bloodstream. |
ADRs | Unintended drug effects (side effects, allergic reactions). |
Anaphylactic Reaction | Severe allergic reaction requiring emergency treatment. |
Bioavailability | Amount of drug available to act on target tissues. |
Distribution | Transport of drug in the bloodstream to tissues. |
Drug Tolerance | Decreased response to a drug over time. |
Excretion | Removal of drugs from the body (mainly by kidneys). |
Generic Name | Non-proprietary drug name. |
Half-life | Time for the drug concentration to decrease by half. |
Idiosyncratic Effect | Unusual or unexpected drug response. |
Inhalation | Drug administered through the lungs. |
Intramuscular (IM) | Injection into muscle tissue. |
Intravenous (IV) | Injection into a vein. |
Medication Reconciliation | Ensuring consistency in medications across care settings. |
Metabolism | Process by which the body breaks down a drug. |
Parenteral | Drug administered by injection. |
Pharmacodynamics | Drug action on the body. |
Pharmacokinetics | How the body processes a drug (ADME). |
Pharmacology | Study of drugs and their effects on the body. |
Pharmacotherapeutics | Use of drugs to treat diseases. |
Piggyback Delivery System | Secondary IV infusion alongside primary infusion. |
Placebo | Inactive substance used in trials. |
PRN Order | Medication given as needed. |
Stat Order | Medication given immediately. |
Subcutaneous Injection | Injection into the fat layer. |
Synergistic Effect | Combined drug effect greater than individual effects. |
Teratogenic | Causes harm to a developing fetus. |
Therapeutic Range | Drug concentration range that produces the desired effect. |
Toxic Effects | Harmful effects due to drug accumulation. |
Trade Name | Brand name given by manufacturer. |
Trough Level | Lowest concentration of a drug before next dose. |
Vial | Container for injectable medications. |
Z-Track Technique | IM injection technique to prevent skin staining and irritation. |