Pathophysiology
• Acute episode = spasm of smooth muscle around bronchi/bronchioles → marked luminal narrowing.
• Consequence: inadequate O₂ in / CO₂ out → potential fatal hypoxia / hypercarbia.
Pre-appointment history checklist
• "What type of asthma do you have?" – \text{Allergic} vs \text{Non-allergic}.
• Non-allergic often precipitated by fear / anxiety / inadequate pain control.
• Ask: "What are you allergic to?" (aspirin common trigger).
• Current meds: rescue bronchodilator (e.g., albuterol) ± daily inhaled corticosteroid.
• Frequency & triggers of attacks; recent attacks in dental chairs? fear of dentistry = red flag.
• History of attacks that "did not stop" or hospitalization → determines need to pre-alert 911.
Preventive office strategies
• Advise pt during confirmation call to bring own inhaler (rescue med).
• Consider prophylactic sedation if stress-induced attacks likely.
In-office management of an attack
• Immediately sit pt upright (easier diaphragmatic excursion).
• Encourage self-administration of rescue inhaler placed on bracket tray.
• Typical dose: 2 puffs; reassess after 5 min; may repeat.
• If pt, provider, or situation remains uncomfortable → terminate procedure, reschedule, treat underlying fear before resuming care.
• Office backup: own bronchodilator if pt’s fails.
Immunology crash-course
• Allergen binds to sensitized mast-cell receptors → degranulation → release of chemical mediators (primarily histamine).
• Histamine actions: itching, urticaria, rash, bronchospasm, vasodilation, edema.
• Severity depends on speed + site of mediator release:
– Skin-only = pruritus / rash (non-life-threatening).
– Lungs = bronchospasm.
– CVS = vasodilation ↓BP + edema → anaphylaxis.
Classification by onset
• Late (delayed) onset: signs ≥ 1 h post-exposure; usually cutaneous; e.g., pt who took prophylactic penicillin developed mild rash.
• Immediate onset: seconds–minutes; involves skin + airway and/or CVS = true anaphylaxis.
Management algorithm (PABCD)
• P – Position: unconscious → supine; conscious → whatever eases breathing.
• A/B/C – assess, support airway, breathing, circulation; instruct staff to call 911.
• D – Definitive drug: Epinephrine 0.3–0.5 mg IM mid-thigh ASAP; repeat q 5 min until recovery or ALS arrives.
– Benefits: potent bronchodilation + vasopressor (restores BP).
– No absolute contraindication when anaphylaxis suspected.
• After epi & once pt stable → administer antihistamine (e.g., diphenhydramine) to blunt residual histamine.
Error chain
• Wrong treatment plan: four-quadrant dentistry in one visit on child.
• Wrong drug: long-acting LA w/ vasoconstrictor when short-acting sufficient.
• Injecting every quadrant sequentially.
• Using full cartridge 1.8\,\text{mL} per site when fraction would suffice.
Toxicity timeline
• Peak blood level ≈ 5 min post-injection; first manifestation often generalized seizure <60 s.
• If airway not maintained post-seizure → hypoxia + hypercarbia ↓ seizure threshold → second, longer seizure 2–3 min later.
Management
• Secure airway, deliver \ge 5\,\text{L/min} O₂.
• Prevent hypoxia / hypercarbia to avoid recurrence.
• Monitor vitals until drug redistributes & pt recovers.
Pathogenesis
• Atherosclerotic plaque buildup in coronary walls → chronic inflammation → luminal narrowing.
• Stress/effort ↑ myocardial O₂ demand; narrowed lumen can’t augment supply → ischemia.
Angina Pectoris
• Ischemic chest discomfort: tight/heavy; pt may clench fist over sternum (Levine sign).
• Usually known dx; relieved by vasodilator (nitroglycerin).
Myocardial Infarction (MI)
• Plaque rupture → platelet aggregation → thrombus occludes artery → downstream myocardium ischemic → necrosis.
• Ischemic tissue electrically unstable → arrhythmias → sudden cardiac arrest.
• "Golden window": reperfusion (balloon angioplasty or thrombolytics) within 2 h → minimal damage.
Chair-side differentiation & first aid
• Persistent pain after 3 doses nitro (q 5 min) OR first-ever chest pain → treat as MI.
• Immediate steps (MONA):
– Morphine IV (or 50\% N₂O/O₂ mix if available) for pain & anxiety.
– Oxygen 5 L/min via mask or cannula.
– Nitroglycerin sub-lingual or spray up to 3 doses unless hypotensive.
– Aspirin 325 mg chew & swallow if no contraindication (allergy, GI bleed, anticoag tx).
• Always activate EMS early.
• Typical MI pain scale: 10/10; may radiate to epigastrium, L-arm (pinky tingling), L-neck, L-mandible; pt pale, diaphoretic, anxious but conscious.