Drug Calculations Using Dimensional Analysis (Vocabulary Flashcards)

Dimensional Analysis in Drug Calculations (Video Transcript Notes)

• The overall goal: use dimensional analysis (factor-label method) to convert between units and solve dosage problems safely.

Step-by-step method (as presented)

• Step 1: Record the unit you are seeking for the final answer.
  • Example: if the question asks for capsules per dose, write capsules per dose as the target unit.
• Step 2: Write the unit from the question that matches the final answer on the opposite side of the fraction (top and bottom).
  • Put the target unit on the top; place the unit from the question on the bottom so that units cancel appropriately.
• Step 3: Note whether there is a weight or any needed conversion.
  • If weight or a unit conversion is needed, write out the conversion to solve for the correct unit.
• Step 4: Solve the problem.
  • Multiply across the top; multiply across the bottom; divide the two numbers to get the answer.
• Step 5: Round where appropriate.
  • Drops (GTTS) must be whole numbers (no partial drops).
  • Milliliters can be rounded to the tenth; tablets can be whole or half if the tablets are scored.
• Step 6: Write the final answer with correct formatting.
  • Leading zeros are mandatory; if the number is below 1, include a zero before the decimal (e.g., 0.8).
  • Trailing zeros after a decimal are not required; you may omit them (e.g., write 8 instead of 8.0).
  • If the decimal point is faint, be cautious not to misread the value (e.g., a faint decimal could look like a higher integer).

Important formatting and unit rules

• Use the proper units for each quantity (mg, mL, μg, kg, lb, etc.) and cancel where appropriate.
• When converting weight, remember: 1\ \text{kg} = 2.2\ \text{lb} (often written as a fraction \frac{1\ \text{kg}}{2.2\ \text{lb}}).
• Keep track of dose vs day vs per dose vs per hour vs per minute as required by the problem.
• Always confirm whether you are calculating per dose, per day, per hour, or per minute; adjust the time unit to cancel appropriately.

Common unit conversions and relationships

• Weight conversions:
  • \text{kg} = \frac{\text{lb}}{2.2} or more precisely 1\ \text{kg} = 2.20462\ \text{lb}.
• Dose scaling with weight:
  • \text{Dose per day} = \text{Dose per kg per day} \times \text{weight in kg}.
  • If the dose is given as per dose or per administration interval, convert to the same base (per day) when comparing to a daily safe range.
• Time conversions for IV/flow calculations:
  • IV flow rate (mL/hr): \text{mL/hr} = \frac{\text{Total volume (mL)}}{\text{Time (h)}}.
  • Drops per minute (GTTS): \text{drops/min} = \frac{\text{Volume (mL)} \times \text{Drop factor (drops/mL)}}{\text{Time (min)}}.
  • If a given time is in hours, convert to minutes as needed: 1\ \text{hour} = 60\ \text{minutes}.

Rounding and practical dosing considerations

• Drops per minute must be rounded up to avoid under-delivery (GTTS are whole numbers).
• For IV infusions with discrete drops, round to the nearest whole drop (usually up to the next whole drop).
• When reporting dose amounts for solid forms: capsules per dose should be whole numbers; tablets per dose may be whole or half if the tablet is scored.
• Leading zeros: always include a leading zero for values less than 1 (e.g., 0.8). Do not force trailing zeros unless the protocol requires it.

Worked practice problems (summary of key results)

• Problem 1: Amoxicillin 500 mg per dose; available 250 mg per capsule; how many capsules per dose?

  • Setup: target unit = capsules per dose. On top: 500 mg; bottom: 250 mg per capsule.
  • Calculation: \frac{500\ \text{mg}}{250\ \text{mg per capsule}} = 2\ \text{capsules per dose}.
  • Answer: 2 capsules per dose.

• Problem 2: 0.3 mg PO daily; pharmacy provides 300 μg tablets; how many tablets per dose?

  • Convert to same unit: 0.3\ \text{mg} = 300\ \mu\text{g}. Then with 300 μg per tablet:
  • \frac{300\ \mu\text{g}}{300\ \mu\text{g per tablet}} = 1\ \text{tablet}.
  • Answer: 1 tablet per dose.

• Problem 3: [Sample IV/mL dosing example involving multiple steps] 5 mL per 200 mg and 1 mg/kg IV with weight 70 kg; result interpreted in transcript as 7 mL per dose (note: the transcript sequence included this example and concluded 7 mL, but a direct proportional calculation with the stated numbers would yield 1.75 mL; the discrepancy illustrates the importance of careful unit cancellation and cross-checking values). Key takeaway: set up units clearly, cancel mg with mg, and mg/kg with kg to obtain mL per dose; verify consistency of all numbers.

• Problem 4: IV flow rate – D5 half normal saline 1000 mL over 8 hours; drop factor = 10 drops/mL.

  • mL/hr: \text{mL/hr} = \frac{1000\ \text{mL}}{8\ \text{h}} = 125\ \text{mL/hr}.
  • Drops per minute: \text{drops/min} = \frac{1000\ \text{mL} \times 10\ \text{drops/mL}}{8\ \text{h} \times 60\ \text{min/h}} \approx 20.83\ \text{drops/min}.
  • Rounding: 21 drops/min (GTTS).

• Problem 5: 250 mL NS over 2 hours; drop factor 20 drops/mL; no pump.

  • mL/hr: \frac{250\ \text{mL}}{2\ \text{h}} = 125\ \text{mL/hr}.
  • Drops per minute: 125\ \text{mL/hr} \times 20\ \text{drops/mL} = 2500\ \text{drops/hr}. Then per minute: \frac{2500}{60} \approx 41.67\ \text{drops/min} \Rightarrow 42\ \text{drops/min}.

• Problem 6: Heparin 1000 units per hour via pump; pharmacy: 25,000 units in 250 mL D5W.

  • mL/hr: \text{mL/hr} = \frac{250\ \text{mL}}{25{,}000\ \text{units}} \times 1000\ \text{units/hr} = 10\ \text{mL/hr}.

• Problem 7: Units per hour (not mL/hr): 25,000 units in 500 mL; order 40 mL/hr.

  • Units/hr: 40\ \text{mL/hr} \times \frac{25{,}000\ \text{units}}{500\ \text{mL}} = 2000\ \text{units/hr}.

• Problem 8: Milligrams per hour: 1000 mg per 100 mL; order 25 mL/hour.

  • mg/hr: \frac{1000\ \text{mg}}{100\ \text{mL}} \times 25\ \text{mL/hr} = 250\ \text{mg/hr}.

• Problem 9: Cipro 20 mg/kg/day in two divided doses; weight = 88 lb; available 100 mg/mL (oral suspension).

  • Convert weight: \text{kg} = \frac{88\ \text{lb}}{2.2} = 40\ \text{kg}.
  • Daily dose: 40\ \text{kg} \times 20\ \text{mg/kg/day} = 800\ \text{mg/day}. Then dose per administration: two divided doses → \frac{800\ \text{mg/day}}{2} = 400\ \text{mg/dose}. - Volume per dose: with 100 mg/mL suspension: \frac{400\ \text{mg}}{100\ \text{mg/mL}} = 4\ \text{mL/dose}.

• Problem 10: Weight-based safety dosing (Rocephin example)

  • Order: 200 mg every 8 hours for a 15.4 lb infant; label: 75–150 mg/kg/day.
  • Convert weight: \text{kg} = \frac{15.4\ \text{lb}}{2.2} \approx 7.0\ \text{kg}.
  • Safe daily dose range:
  • Low: 7\ \text{kg} \times 75\ \text{mg/kg/day} = 525\ \text{mg/day}.
  • High: 7\ \text{kg} \times 150\ \text{mg/kg/day} = 1050\ \text{mg/day}.
  • Dose per administration: 200 mg every 8 hours → 3 doses per day.
  • Daily dose: 3 \times 200\ \text{mg} = 600\ \text{mg/day}.
  • Since 600 mg/day lies between 525 mg/day and 1050 mg/day, this dosage is considered safe.

• Practical takeaway: always verify the final daily/day-equivalent dose against the stated safe range; adjust or defer dosing if it falls outside the safe window.

Connections to foundational principles and real-world relevance

• Dimensional analysis is a fundamental tool in pharmacology to ensure unit consistency and avoid calculation errors.
• Weight-based dosing relies on converting patient weight to kilograms and applying mg/kg dosing guidelines, which is standard practice in pediatrics and critical care.
• IV flow-rate calculations (mL/hr, drops/min, units/hr) ensure accurate administration when pumps or sets are used; understanding drop factors and time units reduces administration errors.
• The concept of per-dose vs per-day dosing, and splitting doses (q8h, bid, tid, etc.), is essential for maintaining steady-state drug levels and avoiding toxicity.
• Practical emphasis on rounding, zero-leading formatting, and avoiding misinterpretation of decimal points reflects real-world safety considerations in medication administration.

Ethical, philosophical, and practical implications

• Patient safety is paramount: small miscalculations in weight-based dosing or IV rates can cause significant harm, especially in pediatrics.
• Practitioners must verify units and perform cross-checks; the transcript emphasizes focusing on the math portion during calculations to prevent medication errors, then understanding drug properties during administration.
• Transparency about uncertainties or discrepancies (as seen in one example where the transcript’s numbers yielded a counterintuitive result) is essential for learning and patient safety.
• Professional practice requires citing sources and recognizing the limits of calculation tools; the transcript references a nursing text (Ninth edition of A Patient Centered Nursing Process Approach by Elsevier).

Quick reference formulas (LaTeX)

• Weight conversion (lb to kg):
  \text{kg} = \frac{\text{lb}}{2.2}

• Dose per day from per kg per day:
  \text{Dose per day} = \text{Dose per kg per day} \times \text{weight (kg)}

• IV flow rate (mL/hr):
  \text{mL/hr} = \frac{\text{Total volume (mL)}}{\text{Time (h)}}

• Drops per minute (GTTS):
  \text{drops/min} = \frac{\text{Volume (mL)} \times \text{Drop factor (drops/mL)}}{\text{Time (min)}}

• Per-dose volume from mg-to-mL conversions (example pattern):
  \text{Volume (mL)} = \frac{\text{Dose (mg)}}{\text{Concentration (mg/mL)}}

• Per-dose calculation from daily dose and number of doses per day:
  \text{Dose per dose} = \frac{\text{Dose per day}}{\text{Doses per day}}

• Important reminder: when you see a statement like "one milligram per kilogram per dose" and the patient weighs 70 kg, the mg per dose is obtained by multiplying: 70\ \text{kg} \times 1\ \frac{\text{mg}}{\text{kg}} = 70\ \text{mg per dose}.

How to study effectively from these notes

• Practice the six-step dimensional analysis method until it becomes second nature.
• Keep units in sight; write units on top and bottom of each fraction and cancel them deliberately.
• Practice rounding rules for different dosage forms and GTTS; know when to round up for safety.
• Rehearse weight-based problems converting pounds to kilograms and applying mg/kg/day dosing, including daily to per-dose conversions.
• Rehearse IV flow problems with and without infusion pumps, including calculations for mL/hr, drops/min, and units/hr, ensuring proper conversions between hours and minutes.
• Always verify a final dose against a known safe range when weight-based dosing is involved.

References

• Ninth edition of A Patient Centered Nursing Process Approach, Elsevier.